13 July 2020>: Clinical Research
Long-Chain Non-Coding RNA Metastasis-Related Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes the Proliferation and Migration of Human Pulmonary Artery Smooth Muscle Cells (hPASMCs) by Regulating the MicroRNA-503 (miR-503)/Toll-Like Receptor 4 (TLR4) Signal Axis
Meng He 1ABCDEF , Juxin Shen 1ABCDF , Chunyi Zhang 1ABCD , Yefeng Chen 1BCDF , Weisi Wang 2BCD , Kelong Tao 3EG*DOI: 10.12659/MSM.923123
Med Sci Monit 2020; 26:e923123
Figure 6 Long-chain non-coding RNA metastasis-related lung adenocarcinoma transcript 1 (lncRNA MALAT1) and microRNA-503 (miR-503) regulate the expression of toll like receptor-4 (TLR-4). (A) Levels of TLR4 mRNA expression on hPASMCs with silenced or overexpressed lncRNA MALAT1. (B) Effect of TLR4 protein expression on hPASMCs cells with silenced or overexpressed by lncRNA MALAT1. (C) TLR4 protein expression levels in hPASMC cells transfected with sh-MALAT1, miR-503 inhibitor, sh-MALAT1+miR-503 inhibitor, or no template control (NC). (D) TLR4 protein expression levels in hPASMC cells transfected with miR-503 mimic, pcDNA-MALAT1, pcDNA-MALAT1+miR-503 mimic, or NC. * p<0.05 compared with the NC group.