15 September 2020>: Lab/In Vitro Research
Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3–Cyclophilin A (CypA) Signaling Pathway
Xiaobo Zhang ABCDEFG* , Ying Zhu BCDEF , Ying Zhou BCDE , Bingru Fei CDEDOI: 10.12659/MSM.922979
Med Sci Monit 2020; 26:e922979
Figure 2 IL-37 reduces inflammation and oxidative stress of high glucose-treated podocytes. The expression of the inflammatory cytokines TNF-α (A), IL-1β (B), and IL-6 (C) as well as the oxidative stress-related molecules MDA (D), LDH (E), and SOD (F) was detected by ELISA. *** p<0.001 vs. NG; ### p<0.001 vs. MA; & p<0.05, && p<0.01, &&& p<0.001 vs. HG. NG – normal glucose group (medium with 5.5 mM glucose); MA – mannitol-treated podocytes used as the osmotic pressure control group; HG – high-glucose group (medium with 30 mM glucose).