Figure 9 (A, B) NORAD could regulate ERK signaling via targeting AKR1B1. The expression of p-ERK was measured using western blotting. All experiments were repeated 3 times independently (n=3). *** P<0.001 vs. si-NC; # P<0.05 vs. si-NORAD-2+pcDNA-NC. NORAD – noncoding RNA activated by DNA damage; ERK – extracellular signal-regulated kinase; p-ERK – phosphorylated ERK; si-NC – negative control for NORAD siRNA; si-NORAD – small interfering RNAs (siRNAs) against NORAD; pcDNA-NC – empty vector plasmid.