Ginkgo biloba Extract EGb761 Attenuates Bleomycin-Induced Experimental Pulmonary Fibrosis in Mice by Regulating the Balance of M1/M2 Macrophages and Nuclear Factor Kappa B (NF-κB)-Mediated Cellular Apoptosis

Ling Pan; Yuehong Lu; Zhanhua Li; Yuping Tan; Hongmei Yang; Ping Ruan; Ruixiang Li

doi:10.12659/MSM.922634

16 August 2020: Animal Study

Extract EGb761 Attenuates Bleomycin-Induced Experimental Pulmonary Fibrosis in Mice by Regulating the Balance of M1/M2 Macrophages and Nuclear Factor Kappa B (NF-κB)-Mediated Cellular Apoptosis

Ling Pan ^AD* , Yuehong Lu ^BCE , Zhanhua Li ^BCEF , Yuping Tan ^BF , Hongmei Yang ^BF , Ping Ruan ^CDF , Ruixiang Li ^BF

DOI: 10.12659/MSM.922634

Med Sci Monit 2020; 26:e922634

Authors information Article notes Copyright and License information

View HTML version

Figure 3 EGb761 suppresses bleomycin (BLM)-induced proinflammatory cytokines in the early stage. Mouse peripheral blood was collected on day 7 after BLM treatment. Levels of proinflammatory cytokines in serum, including tumor necrosis (TNF)-a (A), interleukin (IL)-1β (B), and IL-6 (C), were detected by enzyme-linked immunosorbent assay kit. All data are shown as mean±standard deviation (n=5). ** P<0.0001 vs. normal group; ## P<0.0001 vs. BLM group.

Back to the Article

Extract EGb761 Attenuates Bleomycin-Induced Experimental Pulmonary Fibrosis in Mice by Regulating the Balance of M1/M2 Macrophages and Nuclear Factor Kappa B (NF-κB)-Mediated Cellular Apoptosis

Your Privacy