17 June 2020>: Database Analysis
Coexpression Analysis of the EZH2 Gene Using The Cancer Genome Atlas and Oncomine Databases Identifies Coexpressed Genes Involved in Biological Networks in Breast Cancer, Glioblastoma, and Prostate Cancer
Jin Zhu 1AG* , Lu Jin 1CEF* , Aili Zhang 2BCD* , Peng Gao 1DF , Guangcheng Dai 1BF , Ming Xu 1CF , Lijun Xu 1AD* , Dongrong Yang 1AEG*DOI: 10.12659/MSM.922346
Med Sci Monit 2020; 26:e922346
Figure 5 The impact of EZH2 and coexpressed genes on the overall survival (OS) of patients with cancer. Increased expression of EZH2 and the five most frequently expressed genes (MCM4, KIAA0101, MKI67, RRM2, and CDC25A) are associated with a lower survival rate in breast cancer, gastric cancer, liver cancer, and lung cancer. In lung cancer, the 15 most commonly expressed genes are also analyzed. Increased expression of nine genes (TOP2A, CCNB2, BUB1, BUB1B, CDK1, CCNB1, TPX2, FANCI, and CENPA) predict a lower overall survival. Tumor suppressor genes, PTEN, RB, and TSLC1, are used as negative controls.