24 August 2020: Animal Study
Qi-Xian Decoction Upregulated E-cadherin Expression in Human Lung Epithelial Cells and Ovalbumin-Challenged Mice by Inhibiting Reactive Oxygen Species-Mediated Extracellular-Signal-Regulated Kinase (ERK) Activation
Lingling Tang 1BCDG* , Linyun Zhu 1BCD* , Wei Zhang 2CDF* , Xiaoyan Yang 1DE , Qingge Chen 1DG , Ziyu Meng 1D , Jinjin Liu 1E , Yipeng Sun 1F , Junsheng Hu 1F , Zhenhua Ni 3AEG* , Xiongbiao Wang 1AEG*DOI: 10.12659/MSM.922003
Med Sci Monit 2020; 26:e922003
Figure 1 QXT increased E-cadherin expression in OVA-challenged mice. (A) The lung tissues of OVA-challenged mice were examined with hematoxylin and eosin (×100). Infiltration of eosinophils was shown by black arrows and smooth muscle thickening was shown by red arrows (n=8). (B) Serum IgE levels were estimated using ELISA (n=8). (C) E-cadherin levels were determined by Western blot analysis (n=8). (D) E-cadherin protein concentrations were quantified by using Image J software and normalized to β-actin. Data are shown as the mean±standard, * P<0.05, ** P<0.01.