05 July 2020>: Animal Study
Therapeutic Effect of Berberine on Insomnia Rats by ErbB Signaling Pathway
Qingquan Wang 1ABE , Xiaojuan Ren 1C , Xingping Zhang 1DG* , Guanying Wang 1D , Hongxia Xu 1C , Ning Deng 2F , Tao Liu 1D , Zhipeng Peng 1BDOI: 10.12659/MSM.921831
Med Sci Monit 2020; 26:e921831
Figure 4 Enrichment analysis was used to identify the molecular regulatory mechanism of berberine therapy. (A) The key genes involved in GO function in berberine therapy. (B) The key genes involved in KEGG signaling pathway in berberine therapy. (C) Phosphorylation of ErbB2 and ErbB4 proteins. * P<0.05, ** P<0.01, *** P<0.001 versus model group. GO – Gene Ontology; KEGG – Kyoto Encyclopedia of Genes and Genomes.