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15 June 2020: Clinical Research

LncRNA LINC00152 Increases the Aggressiveness of Human Retinoblastoma and Enhances Carboplatin and Adriamycin Resistance by Regulating MiR-613/Yes-Associated Protein 1 (YAP1) Axis

Ying Wang CDE* , Danli Xin ABCE , Lei Zhou BCDF

DOI: 10.12659/MSM.920886

Med Sci Monit 2020; 26:e920886

Figure 1 The expression levels of LINC00152 and miR-613 in retinoblastoma tissues and cells. (A) RT-qPCR was used to analyze the expression level of LINC00152 in retinoblastoma tissues and normal retina tissues. (B) The survival curves of retinoblastoma patients were plotted using the Kaplan-Meier method with the log-rank test. (C) The expression level of miR-613 was assessed by RT-qPCR assay in retinoblastoma tissues and normal retina tissues. (D) The correlation relationship between miR-613 and LINC00152 was analyzed. (E) The expression levels of LINC00152 and miR-613 in 4 human retinoblastoma cell lines RBL-13, Y79, Weri-RB-1, and SO-RB50 and human retinal pigment epithelial cell line ARPE-19 were elevated using RT-qPCR assay. ** P<0.01. RT-qPCR – real-time quantitative polymerase chain reaction.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750