H-Index
70
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 1643-3750


Published: 2019-01-23

The Association Between Vitamin D Status, Vitamin D Supplementation, Sunlight Exposure, and Parkinson’s Disease: A Systematic Review and Meta-Analysis

Zonglei Zhou, Ruzhen Zhou, Zengqiao Zhang, Kunpeng Li

(Department of Epidemiology and Biostatistics, Sichuan University West China School of Public Health, Chengdu, Sichuan, China (mainland))

Med Sci Monit 2019; 25:666-674

DOI: 10.12659/MSM.912840


BACKGROUND: This literature review and meta-analysis aimed to determine the association between deficiency of vitamin D, or 25-hydroxyvitamin D, and Parkinson’s disease, and whether vitamin D from supplements and sunlight improves the symptoms of Parkinson’s disease.
MATERIAL AND METHODS: A literature review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Systematic literature review was performed using databases that included the Web of Science, PubMed, the Cochrane Library, and Embase. The Jadad scale (the Oxford quality scoring system) and the Newcastle-Ottawa scale (NOS) were used to evaluate the quality of the studies.
RESULTS: Eight studies were included in the meta-analysis. Both 25-hydroxyvitamin D insufficiency (<30 ng/mL) (OR, 1.77; 95% CI, 1.29–2.43; P<0.001) and deficiency (<20 ng/mL) (OR, 2.55; 95% CI, 1.98–3.27; P<0.001) were significantly associated with an increased risk of Parkinson’s disease when compared with normal controls Sunlight exposure (³15 min/week) was significantly associated with a reduced risk of Parkinson’s disease (OR, 0.02; 95% CI, 0.00–0.10; P<0.001). The use of vitamin D supplements was effective in increasing 25-hydroxyvitamin D levels (SMD, 1.79; 95% CI, 1.40–2.18; P<0.001), but had no significant effect on motor function (MD, –1.82; 95% CI, –5.10–1.45; P=0.275) in patients with Parkinson’s disease.
CONCLUSIONS: Insufficiency and deficiency of 25-hydroxyvitamin D and reduced exposure to sunlight were significantly associated with an increased risk of Parkinson’s disease. However, vitamin D supplements resulted in no significant benefits in improving motor function for patients with Parkinson’s disease.

Keywords: Calcitriol, meta-analysis, Parkinson Disease, Sunlight



Related Articles (0)

Coming Soon...

Published: 2019-01-23

Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Sign...


Huihui Li, Yue Wang

Med Sci Monit 2019; 25:656-665

DOI: 10.12659/MSM.912813

Published: 2019-01-22

Identification of Recent Trends in Research on Vitamin D: A Quantitative and Co-Word Analysis


Aolin Yang, Qingqing Lv, Feng Chen, Difei Wang, Ying Liu, Wanying Shi

Med Sci Monit 2019; 25:643-655

DOI: 10.12659/MSM.913026