eISSN: 1643-3750


Published: 2016-10-22

The Association Between the Genetic Variants of the NOTCH3 Gene and Ischemic Stroke Risk

Xiaoling Yuan, Zifeng Dong

(Department of Neurology, People’s Hospital of Liaocheng, Liaocheng, Shandong, China (mainland))

Med Sci Monit 2016; 22:3910-3914

DOI: 10.12659/MSM.896297

BACKGROUND: Ischemic stroke (IS) is a leading cause of disability and death and NOTCH3 as a gene related with cardiac-cerebral vascular disease plays a vital role in IS development. However, the reports about the effect of genetic variants in NOTCH3 gene on IS are still few.
MATERIAL AND METHODS: In order to explore the association between NOTCH3 polymorphisms and IS, 134 patients with IS and 115 controls were enrolled in this case-control study. Polymerase chain reaction was used to do the genotyping of polymorphisms. The χ² test was performed to evaluate Hardy-Weinberg equilibrium (HWE) in the control group and calculate odds ratio (OR) with corresponding 95% confidence interval (CI) which represented the association intensity of NOTCH3 gene polymorphisms and IS risk.
RESULTS: The genotype frequencies in the control group all confirmed to HWE. TT genotype of 381C>T was associated significantly with IS risk (OR=2.441, 95%CI=1.021–5.837). TC, CC mutant genotypes of 1735T>C had higher frequencies in cases than controls and the difference was significant (P=0.013, 0.041); further, its C allele also increased 0.722 times risk in the case group than controls (OR=1.722, 95%CI=1.166–2.541).
CONCLUSIONS: NOTCH3 381C>T and 1735T>C polymorphisms were associated with IS and might be the risk factors for IS development, but not NOTCH3 605C>T polymorphism.

Keywords: Association, Optic Neuropathy, Ischemic, Polymorphism, Genetic

Related Articles (0)

Coming Soon...

Published: 2016-10-22

Inhibiting MicroRNA-503 and MicroRNA-181d with Losartan Ameliorates Diabetic Nephropathy in KKAy Mice

XinWang Zhu, CongXiao Zhang, QiuLing Fan, XiaoDan Liu, Gang Yang, Yi Jiang, LiNing Wang

Med Sci Monit 2016; 22:3902-3909

DOI: 10.12659/MSM.900938

Published: 2016-10-22

MicroRNA-16 Alleviates Inflammatory Pain by Targeting Ras-Related Protein 23 (RAB23) and Inhibiting p38 M...

Wenjin Chen, Shengdong Guo, Shenggang Wang

Med Sci Monit 2016; 22:3894-3901

DOI: 10.12659/MSM.897580