eISSN: 1643-3750


Published: 2016-12-07

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Chaolan Lv, Hongxiang Gu, Xinmei Zhao, Liyun Huang, Sanxi Zhou, Fachao Zhi

(Department of Gastroenterology, Anhui Provincial Hospital, Hefei, Anhui, China (mainland))

Med Sci Monit 2016; 22:4794-4802

DOI: 10.12659/MSM.902274

BACKGROUND: Activated Cdc42 kinase1 (ACK1) is a non-receptor tyrosine kinase which is critical for cell survival, proliferation, and migration. Genomic amplification of ACK1 has been reported in multiple human cancers. We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity.
MATERIAL AND METHODS: A total of 250 individuals who underwent total colonoscopy were collected randomly from January 2007 to May 2013 in Nanfang Hospital, Guangzhou, China. Colorectal mucosal biopsy specimens were obtained by endoscopy from 78 patients with ulcerative colitis (UC), 22 with Crohn’s disease (CD), 20 with infectious colitis, 26 with non-IBD and noninfectious colitis, 16 with sporadic adenomas, 4 with dysplasia-associated lesions or masses, 10 with sporadic colorectal cancer (CRC), 4 with UC-related CRC, 10 with hyperplastic polyps, and 60 without colonic abnormalities. ACK1 protein levels were determined immunohistochemically. The correlations of ACK1 expression with disease activity and severity were also evaluated.
RESULTS: Significantly increased ACK1 expression was observed in epithelial cells of colorectal mucosa with inflammation and dysplasia compared to controls (P<0.05). ACK1 expression correlated with clinical activity in IBD (χ²=4.57, P=0.033 for UC; χ²=5.68, P=0.017 for CD), as well as grade of dysplasia in preneoplastic lesions (P<0.05). No significant differences in ACK1 ex... read more

Keywords: Colitis, Ulcerative, Colorectal Neoplasms, Inflammatory Bowel Diseases

Published: 2016-12-07

P53 and Murine Double Mimute 2 (MDM2) Expression Changes and Significance in Different Types of Endometri...

Zhongyong Jiang, Wanqing Xu, Gang Dan, Yuan Liu, Jie Xiong

Med Sci Monit 2016; 22:4786-4793

DOI: 10.12659/MSM.898616

Published: 2016-12-06

Expression of microRNA-328 Functions as a Biomarker for Recurrence of Early Gastric Cancer (EGC) After En...

Hui-guang Xue, Ai-hua Yang, Xue-guo Sun, Yan-yan Lu, Zi-bin Tian

Med Sci Monit 2016; 22:4779-4785

DOI: 10.12659/MSM.896225