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Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to... read more


Published: 2014-10-25

Elevated Cardiac Markers in Chronic Kidney Disease as a Consequence of Hyperphosphatemia-Induced Cardiac Myocyte Injury

Shu Wang, Ling Qin, Tianfu Wu, Bingqing Deng, Yuerun Sun, Dayong Hu, Chandra Mohan, Xin J. Zhou, Ai Peng

(Department of Nephrology and Rheumatology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China (mainland))

Med Sci Monit 2014; 20:2043-2053

DOI: 10.12659/MSM.890909


Background: Elevated cardiac markers (CMs) and hyperphosphatemia are commonly encountered in patients with chronic kidney diseases (CKD), but the causal relationship between them has not been established.
Material and Methods: We enrolled 151 patients with different kidney functions in a cross-sectional study to explore the relationship of serum phosphorus with CMs, including cardiac troponin T (cTnT), myoglobin (MYO), creatine kinase-MB (CK-MB), and brain natriuretic peptide (BNP). Then, the effect of reducing phosphorus levels on CMs by taking phosphate binder for 3 months was prospectively observed in 64 hemodialysis patients. Finally, human cardiomyocytes were exposed to different concentrations of inorganic phosphorus to examine its underlying mechanism.
Results: 1) Serum phosphorus and CMs gradually increased as the glomerular filtration rate declined in CKD patients (p<0.01). 2) Elevation of CMs was much greater and cardiac structure and function were worse in CKD patients who had higher serum phosphorus concentrations (p<0.05). 3) Serum phosphorus level positively correlated with cTnT, MYO, and BNP in CKD patients (p<0.001). 4) In hemodialysis patients, the reduction of cTnT, MYO, and CK-MB was synchronous with the pharmacologically-induced decline of serum phosphorus level. However, levels of serum Fibroblast growth factor 23 (FGF23) had no statistical decrease. 5) Simulated hyperphosphatemia inhibited proliferation of human cardiomyocytes in a time- and concentration-dependent manner.
Conclusions: Hyperphosphatemia may induce myocardial damage in CKD patients, possibly through triggering apoptosis of hu... read more

Keywords: Apoptosis, Biological Markers, Fibroblast Growth Factors, hyperphosphatemia, Renal Insufficiency, Chronic, Troponin T




Published: 2014-10-24

The Prevalence of Malocclusion and Oral Habits among 5–7-Year-Old Children


Kristina Kasparaviciene, Antanas Sidlauskas, Egle Zasciurinskiene, Arunas Vasiliauskas, Gintaras Juodzbalys, Mantas Sidlauskas, Ugne Marmaite

Med Sci Monit 2014; 20:2036-2042

DOI: 10.12659/MSM.890885

Published: 2014-10-24

Impact of Acoustic Radiation Force Impulse Imaging in Clinical Practice of Patients after Orthotopic Live...


Dane Wildner, Deike Strobel, Peter C. Konturek, Rüdiger S. Görtz, Roland S. Croner, Markus F. Neurath, Steffen Zopf

Med Sci Monit 2014; 20:2027-2035

DOI: 10.12659/MSM.891126