Published: 2014-08-29

Deterioration of Heart Rate Recovery Index in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)

Olcay Ozveren, Orhan Dogdu, Cihan Sengul, Veysel Cinar, Elif Eroglu, Zekeriya Kucukdurmaz, Muzaffer Degertekin

(Department of Cardiology, Yeditepe University, Medical School, Istanbul, Turkey)

Med Sci Monit 2014; 20:1539-1543

DOI: 10.12659/MSM.890741

Background: Non-alcoholic fatty liver disease (NAFLD) has been considered as a benign disease often associated with central obesity and insulin resistance and, in general, with factors of the metabolic syndrome. Heart rate recovery after exercise is a function of vagal reactivation, and its impairment is an independent prognostic indicator for cardiovascular and all-cause mortality. The aim of our study was to evaluate the heart rate recovery index in patients with NAFLD.
Material and Methods: The study population included 59 patients with NAFLD (mean age=42.3±9.3 years) and 22 healthy subjects as controls (mean age=40.7±6.5 years). Basal electrocardiography, echocardiography, and treadmill exercise testing were performed on all patients and controls. The heart rate recovery index was defined as the reduction in the heart rate from the rate at peak exercise to the rate at the 1st minute (HRR1), 2nd minute (HRR2), 3rd minute (HRR3), and 5th minute (HRR5) after stopping exercise stress testing.
Results: There were significant differences in HRR1 and HRR2 indices between patients with ED and the control group (19.9±8.2 vs. 34.1±9.6; p<0.001 and 24.3±5.4 vs. 40.5±9.1; p=0.006, respectively). Similarly, HRR indices after the 3rd and 5th minutes of the recovery period were significantly lower in patients with NAFLD compared with those indices in the control group (32.3±8.5 vs. 58.4±6.5; p=0.001 and 58±18.2 vs. 75.1±15.8; p<0.001). Effort capacity was markedly lower (11... read more

Keywords: Autonomic Nervous System, Fatty Liver, Heart Rate

Published: 2014-08-28

The OSR1 rs12329305 Polymorphism Contributes to the Development of Congenital Malformations in Cases of S...

Bernarda Lozić, Vjekoslav Krželj, Ivana Kuzmić-Prusac, Radenka Kuzmanić-Šamija, Vesna Čapkun, Ružica Lasan, Tatijana Zemunik

Med Sci Monit 2014; 20:1531-1538

DOI: 10.12659/MSM.890916

Published: 2014-08-27

Glucose Metabolism Measured by Positron Emission Tomography is Reduced in Patients with White Matter Pres...

Jian Li, Wenli Hu

Med Sci Monit 2014; 20:1525-1530

DOI: 10.12659/MSM.892137