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Published: 2015-03-03

miR-630 Overexpression in Hepatocellular Carcinoma Tissues is Positively Correlated with alpha-Fetoprotein

Jian-wen Zhang, Yang Li, Xian-Cheng Zeng, Tong Zhang, Bin-Sheng Fu, Hui-Min Yi, Qi Zhang, Nan Jiang

(Department of Hepatic Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland))

Med Sci Monit 2015; 21:667-673

DOI: 10.12659/MSM.892515


Background: MicroRNA-630 (miR-630) has been shown to be involved in various human malignancies. However, its role in hepatocellular carcinoma (HCC) remains unknown.
Material and Methods: TaqMan qRT-PCR assay was performed to detect the expression of miR-630 in 42 pairs of HCC tissues and corresponding noncancerous hepatocellular tissues, and its correlations with clinicopathologic features and serum alpha-fetoprotein (AFP) level of patients were analyzed.
Results: The present study found that miR-630 expression was significantly increased in HCC tissues and cells compared with their normal counterparts. miR-630 expression level did not significantly chang at stage I but was markedly increased at advanced TNM stage (stage II~III). In addition, the increased expression of miR-630 in tissues of HCC appeared in patients who exhibited elevated serum levels of AFP (>25 ng/ml), but not in those with normal AFP levels (≤25 ng/ml). The miR-630 expression in carcinoma tissues revealed a positive correlation with the levels of serum alpha-fetoprotein (AFP; R2=0.768).
Conclusions: These results suggest that miR-630 is associated with tumor progression of hepatocellular carcinoma and may be a potential prognosis indicator.

Keywords: alpha-Fetoproteins, Carcinoma, Hepatocellular, MicroRNAs




Published: 2015-03-03

Concurrent Chemoradiotherapy with Vinorelbine plus Split-Dose Cisplatin may be an Option in Inoperable St...


Hüseyin Mertsoylu, Fatih Köse, Ahmet Taner Sümbül, Ali Murat Sedef, Özlem Doğan, Ali Ayberk Besen, Cem Parlak, Alper Fındıkçıoğlu, Sadık Muallaoğlu, Ahmet Sezer, Hakan Sakallı, Özgür Özyılkan

Med Sci Monit 2015; 21:661-666

DOI: 10.12659/MSM.892730

Published: 2015-03-02

Factors Related to Long-Term Post-Stroke Cognitive Impairment in Young Adult Ischemic Stroke


Ying Huang, Shanshan Yang, Jianping Jia

Med Sci Monit 2015; 21:654-660

DOI: 10.12659/MSM.892554