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Published: 2015-08-02

Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases

Yin-Peng Huang, Tian-Yi Wang, Wei Wang, Hong-Zhi Sun

(Department of General Surgery, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, China (mainland))

Med Sci Monit 2015; 21:2240-2250

DOI: 10.12659/MSM.893453


BACKGROUND: Aberrant expression of defensins is implicated in the pathogenesis of digestive diseases. However, the contribution of specific defensins and the influence of their genetic polymorphisms on the progression of digestive diseases remain controversial. In the present meta-analysis, we investigated the association between DEFB1 SNPs and the susceptibility to digestive diseases.
MATERIAL AND METHODS: Case-control studies that reported the correlation between DEFB1 SNPs and the susceptibility to digestive diseases were identified through electronic databases searches, and high-quality studies that satisfied our inclusion criteria were selected for this meta-analysis. Statistical analyses were performed utilizing STATA software version 12.0.
RESULTS: The present meta-analysis revealed that patients with digestive diseases exhibited higher frequencies of the DEFB1 genetic variants rs11362G>A, rs1800972C>G, and rs1799946G>A compared to healthy controls under the allele model. Subgroup analysis based on country showed that the rs1800972C>G variant under allele model and rs1799946G>A are associated with the susceptibility to digestive diseases in Hungarian and Italian populations, respectively. Subgroup analysis based on disease type showed that: (1) rs11362G>A variant was strongly associated with severe acute pancreatitis (SAP) and chronic gastritis, (2) frequency of rs1800972C>G variant was higher in SAP subgroup, and (3) frequency of rs1799946G>A variant was positively associated with the susceptibili... read more

Keywords: Digestive System Abnormalities, Disease Susceptibility, meta-analysis, Polymorphism, Genetic




Published: 2015-08-01

Kinesiology Taping does not Modify Electromyographic Activity or Muscle Flexibility of Quadriceps Femoris...


Tomasz Halski, Robert Dymarek, Kuba Ptaszkowski, Lucyna Słupska, Katarzyna Rajfur, Joanna Rajfur, Małgorzata Pasternok, Agnieszka Smykla, Jakub Taradaj

Med Sci Monit 2015; 21:2232-2239

DOI: 10.12659/MSM.894150

Published: 2015-07-31

Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC


Guangyuan Sun, Bing Liu, Jin He, Xuewei Zhao, Bing Li

Med Sci Monit 2015; 21:2225-2231

DOI: 10.12659/MSM.894786