Brain, Liver, and Serum Salusin-alpha and -beta Alterations in Sprague-Dawley Rats with or Without Metabolic Syndrome
Cihan Citil, Vahit Konar, Suleyman Aydin, Musa Yilmaz, Serdal Albayrak, Ibrahim Hanifi Ozercan, Yusuf Ozkan
(Atatürk Vocational School of Health Science, Kafkas University, Kars, Turkey)
Med Sci Monit 2014; 20:1326-1333
This metabolic syndrome (MetS) study was designed to investigate changes in expression of the neuropeptides salusin-α (Sal-α) and salusin-β (Sal-β) in brain and liver tissue in response to obesity and related changes induced by high-fructose diet and explored how these changes were reflected in the circulating levels of Sal-α and Sal-b, as well as revealing how the lipid profile and concentrations of glucose and uric acid were altered.
Material and Methods: The study included 14 Sprague-Dawley rats. The control group was fed ad libitum on standard rat pellets, while the intervention group was given water with 10% fructose in addition to the standard rat pellet for 3 months. Sal-α and Sal-β concentrations in the serum and tissue supernatants...
Keywords: 14-3-3 Proteins, Liver Failure, Acute, Neuroendocrine Secretory Protein 7B2