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Published: 2016-05-26

Improvement of Survival Rate for Patients with Hepatocellular Carcinoma Using Transarterial Chemoembolization in Combination with Three-Dimensional Conformal Radiation Therapy: A Meta-Analysis

Houqiao Bai, Peng Gao, Hao Gao, Guangxi Sun, Chonghai Dong, Jian Han, Guosheng Jiang

(Department of Internal Medicine, Maternity and Child Care, Weihai, Shandong, China (mainland))

Med Sci Monit 2016; 22:1773-1781

DOI: 10.12659/MSM.895548


BACKGROUND: Transarterial chemoembolization (TACE) has been used alone or in combination with three-dimensional conformal radiation therapy (3DCRT) for treating hepatocellular carcinoma (HCC). The overall survival rate of HCC patients undergoing both treatments, however, has not been systematically studied. The aim of this meta-analysis-based study was to evaluate the overall efficacy of the combined therapy or monotherapy, thereby providing information for clinical treatment.
MATERIAL AND METHODS: We searched Google Scholar, PubMed, and Chinese National Knowledge Infrastructure (CNKI) for eligible studies, and a total of 17 case-control studies (including HCC patients treated by TACE plus 3DCRT or TACE alone) were included to perform the meta-analysis. Based on the available data, we assessed the improvements of 1-year, 2-year, and 3-year survival rate for the combination therapy of TACE and 3DCRT or TACE alone. Furthermore, the analysis was also stratified by the tumor response: complete response (CR), partial response (PR), no response (NR) and progressive disease (PD). Statistical analysis was performed using STATA 12 (Stata Statistical Software: Release 12).
RESULTS: The results show that HCC patients receiving combination therapy have significantly increased overall survival rate when compared to those receiving TACE alone (1-year survival rate: OR=1.95, 95% CI 1.54–2.47, p=7.3×10^–8; 2-year survival rate: OR=1.87, 95% CI 1.49–2.34, p=1.6×10^–7; 3-year survival rate: OR=2.00, 95% CI 1.52–2.64, p=1.8×10^–6).
CONCLUSIONS: Assessment of tumor response demonstrates that the combination therapy can efficiently increase th... read more

Keywords: Carcinoma, Hepatocellular, Chemoembolization, Therapeutic, meta-analysis




Published: 2016-05-26

Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Into Neuron-Like Cells In Vitro and Co-Cultured...


Wei Yue, Feng Yan, Yue-Lin Zhang, Shu-Ling Liu, Shu-Ping Hou, Guo-Chao Mao, Ning Liu, Yong Ji

Med Sci Monit 2016; 22:1766-1772

DOI: 10.12659/MSM.898441

Published: 2016-05-25

MicroRNA-184 Modulates Doxorubicin Resistance in Osteosarcoma Cells by Targeting BCL2L1


Bo-chuan Lin, Dong Huang, Chao-qun Yu, Yong Mou, Yuan-hang Liu, Da-wei Zhang, Feng-jun Shi

Med Sci Monit 2016; 22:1761-1765

DOI: 10.12659/MSM.896451