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Published: 2015-03-06

Endolymphatic Hydrops Detected by 3-Dimensional Fluid-Attenuated Inversion Recovery MRI following Intratympanic Injection of Gadolinium in the Asymptomatic Contralateral Ears of Patients with Unilateral Ménière’s Disease

Yupeng Liu, Huan Jia, Jun Shi, Hui Zheng, Yuhua Li, Jun Yang, Hao Wu

(Department of Otolaryngology – Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland))

Med Sci Monit 2015; 21:701-707

DOI: 10.12659/MSM.892383


Background: The aim of this study was to identify the incidence of endolymphatic hydrops using 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) in the contralateral ear in patients with unilateral Ménière’s disease (MD).
Material and Methods: This was a prospective study. 3D-FLAIR MRI was performed with a 3 Tesla (3 T) unit 24 h after the intratympanic administration of gadolinium (Gd) in 30 unilateral MD patients with an asymptomatic contralateral ear. The incidence of contralateral involvement in unilateral MD patients and the potential correlations between the affected and contralateral ears were analyzed.
Results: Endolymphatic hydrops was observed in 7 of the 30 (23.3%) asymptomatic ears. The mean PTA of the asymptomatic ears in the contralateral hydrops patients (33.0±6.1 dB) was significantly higher compared with the non-hydrops patients (17.8±5.7 dB). The patients with observed contralateral hydrops exhibited a significantly longer duration of the disease compared with the non-hydrops patients (6.7±6.3 vs. 2.9±3.1 years, respectively). Furthermore, the patients with contralateral hydrops had a worse hearing level in the affected ears compared with the non-hydrops patients (70.3±7.4 vs. 52.5±3.8 dB, respectively).
Conclusions: Endolymphatic hydrops is closely related to hearing loss but does not necessarily result in Ménière’s symptoms. Patients with a long history of MD and severe hearing loss in the affected ear are more likely to exhibit endolymphatic hydrops in the asymptoma... read more

Keywords: Endolymphatic Hydrops, Hearing Loss, Bilateral, Magnetic Resonance Imaging, Meniere Disease




Published: 2015-03-06

Audio Profiles in Mitochondrial Deafness m.1555A>G and m.3243A>G Show Distinct Differences


Katarzyna Iwanicka-Pronicka, Agnieszka Pollak, Agata Skórka, Urszula Lechowicz, Lech Korniszewski, Przemysław Westfal, Henryk Skarżyński, Rafał Płoski

Med Sci Monit 2015; 21:694-700

DOI: 10.12659/MSM.890965

Published: 2015-03-05

Interferon-γ +874A/T Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis


Huan Zhou, Lizhou Wang, Xing Li, Jie Song, Tianpeng Jiang, Xiaoping Wu, Shi Zhou

Med Sci Monit 2015; 21:689-693

DOI: 10.12659/MSM.892885