Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to... read more

Published: 2014-11-27

Measurement of Free Radicals Using Electron Paramagnetic Resonance Spectroscopy During Open Aorto-Iliac Arterial Reconstruction

Wacław Majewski, Ryszard Krzyminiewski, Michał Stanisić, Maria Iskra, Zbigniew Krasiński, Marek Nowak, Bernadeta Dobosz

(Department of General and Vascular Surgery, Poznań University of Medical Sciences, Poznań, Poland)

Med Sci Monit 2014; 20:2453-2460

DOI: 10.12659/MSM.890774

Background: Aortic cross-clamping during abdominal aortic aneurysm (AAA) open repair leads to development of ischemia-reperfusion injury. Electron paramagnetic resonance spectroscopy (EPR) spin-trapping is a valuable method of direct measurement of free radicals.
The objective of the study was to evaluate the results of EPR as a direct method of free radical measurement and degree of inflammatory response in open operative treatment of patients with AAA and aorto-iliac occlusive disease (AIOD).
Material and Methods: The study was performed on a group of 32 patients with AAA and 25 patients with AIOD scheduled for open repair. Peripheral venous blood for EPR spectroscopy and for SOD, GPx, ox-LDL, Il-6, TNF-alfa, CRP, and HO-1 were harvested. Selected parameters were established accordingly to specified EPR and immunohistochemical methods and analyzed between groups by Mann-Whitney U test and Wilcoxon matched-pairs signed-ranks test with Bonferroni correction.
Results: Free radicals level was correlated with the time of the aortic cross-clamping after the reperfusion of he first and second leg in AAA (r=0.7; r=0.47). ox-LDL in AAA decreased 5 min after reperfusion of the first leg (32.99 U/L, range: 14.09–77.12) and 5 min after reperfusion of the second leg (26.75 U/L, range: 11.56–82.12) and 24 h after the operation (25.85 U/L, range: 14.29–49.70). HO-1concentration increased to above the level before intervention 24 h after surgery. The activities of GPx and SOD decreased 5 min after the first-leg reperfusion in AAA. Twenty-four hours after surgery, inflammatory markers increased in AAA to CRP was 14.76 ml/l (0.23–38.55),... read more

Keywords: Aortic Aneurysm, Abdominal, Aortic Diseases, Electron Spin Resonance Spectroscopy, Ischemic Preconditioning

Published: 2014-11-27

Association between Red Blood Cell Distribution Width and Acute Pancreatitis

Keziban Uçar Karabulut, Hüseyin Narcı, Yıldız Uçar, Mehmet Uyar

Med Sci Monit 2014; 20:2448-2452

DOI: 10.12659/MSM.891075

Published: 2014-11-26

Evidence for Using Alendronate to Treat Adult Avascular Necrosis of the Femoral Head: A Systematic Review

Ru-Bin Luo, Tiao Lin, Hui-Ming Zhong, Shi-Gui Yan, Jian-An Wang

Med Sci Monit 2014; 20:2439-2447

DOI: 10.12659/MSM.891123