Published: 2014-09-17

DPP-4 Inhibitors Improve Liver Dysfunction in Type 2 Diabetes Mellitus

Ippei Kanazawa, Ken-ichiro Tanaka, Toshitsugu Sugimoto

(Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan)

Med Sci Monit 2014; 20:1662-1667

DOI: 10.12659/MSM.890989

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors might have pleiotropic effects because receptors for incretin exist in various tissues, including liver. We examined whether DPP-4 inhibitors affect liver function in patients with type 2 diabetes.
Material and Methods: A retrospective review of 459 patients with type 2 diabetes who were prescribed DPP-4 inhibitors was performed. After exclusion of patients with hepatitis B or C, steroid use, and other diseases that might affect liver function and diabetes status, 224 patients were included in the analysis.
Results: Forty-four patients (19.6%) with liver injury defined by aspartate transaminase (AST) or alanine transaminase (ALT) over the normal level of 40 U/L. In the patients with liver injury, AST and ALT were significantly decreased after 6 months from the first date of DPP-4 prescription, with mean changes of –6.2 U/L [95% confidence interval (CI) –10.9 to –1.4, p=0.012] and of –11.9 U/L (95%CI –19.5 to –4.2, p=0.003), respectively. Percent changes in AST were significantly and negatively correlated with baseline AST and ALT (r=–0.27, p<0.001 and r=–0.23, p=0.002, respectively), and percent changes in ALT were also negatively correlated with them (r=–0.23, p=0.001 and r=–0.27, p<0.001, respectively).
Conclusions: DPP-4 inhibitors improved liver dysfunction in patients with type 2 diabetes.

Keywords: Diabetes Complications, Diabetes Mellitus, Diabetes Mellitus, Type 2, Fatty Liver

Published: 2014-09-16

Polymorphism of ABCB1/MDR1 C3435T in Children and Adolescents with Partial Epilepsy is due to Different C...

Ewa Emich-Widera, Wirginia Likus, Beata Kazek, Aleksander L. Sieroń, Ksymena Urbanek

Med Sci Monit 2014; 20:1654-1661

DOI: 10.12659/MSM.890633

Published: 2014-09-15

The Incidence and Risk Factors of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants...

Ali Riza Cenk Celebi, Ikbal Seza Petricli, Emre Hekimoglu, Nihal Demirel, Ahmet Yagmur Bas

Med Sci Monit 2014; 20:1647-1653

DOI: 10.12659/MSM.892262