eISSN: 1643-3750


Published: 2016-10-24

Association Between Rs3807989 Polymorphism in Caveolin-1 (CAV1) Gene and Atrial Fibrillation: A Meta-Analysis

Wenjun Jia, Xin Qi, Qi Li

(Department of Cardiology, Tianjin Union Medicine Centre, Tianjin, China (mainland))

Med Sci Monit 2016; 22:3961-3966

DOI: 10.12659/MSM.896826

BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia affected by multiple cardiovascular risk factors. It is reported that caveolin-1 gene (CAV1) rs3807989 polymorphism might be associated with AF risk. The goal of this meta-analysis was to confirm the association between CAV1 rs3807989 polymorphism and susceptibility to AF.
MATERIAL AND METHODS: We carried out a comprehensive literature search through the electronic databases PubMed, MEDLIN, and Web of Science. We performed a meta-analysis of all selected studies based on CAV1 rs3807989 polymorphism genotypes, including 3758 cases and 6126 controls.
RESULTS: After meta-analysis with fixed- or random-effects models, we found significant associations in all 5 comparisons: allelic model (G/A; OR=1.228, 95%CI: 1.061–1.420; P=0.006), homozygote model (GG/AA; OR=1.439, 95%CI: 1.094–1.894; P=0.009), heterozygote model (GG/GA; OR=1.257, 95%CI: 1.064–1.486; P=0.007), dominant model (GG/AA+GA; OR=1.287, 95%CI: 1.076–1.540; P=0.006), and recessive model (AA/GA+GG; OR=0.738, 95%CI: 0.629–0.867; P<0.001). Sensitivity analysis results revealed the overall results were robust.
CONCLUSIONS: The results revealed a significant association between CAV1 gene rs3807989 polymorphism and susceptibility to AF, suggesting that the presence of allelic G might be one of the genetic factors conferring susceptibility to AF. To confirm this association, further well-designed studies ... read more

Keywords: Atrial Fibrillation, Caveolin 1, Polymorphism, Single Nucleotide

Published: 2016-10-24

Knockdown of High Mobility Group-Box 3 (HMGB3) Expression Inhibits Proliferation, Reduces Migration, and ...

Shengnan Guo, Yuanyuan Wang, Yu Gao, Yinxu Zhang, Mingzi Chen, Minghao Xu, Lu Hu, Yu Jing, Fangyu Jing, Chen Li, Qingjun Wang, Zhitu Zhu

Med Sci Monit 2016; 22:3951-3960

DOI: 10.12659/MSM.900880

Published: 2016-10-24

Evaluation of Early Atherosclerosis Markers in Patients with Inflammatory Bowel Disease

Yusuf Üstün, Serta Kilincalp, Şahin Çoban, Yusuf Coşkun, İlhami Yüksel, Aydan Ongun, İrfan Soykan, Mehmet Bektaş, Murat Törüner, Hülya Çetinkaya, Necati Örmeci

Med Sci Monit 2016; 22:3943-3950

DOI: 10.12659/MSM.898160