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Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to... read more


Published: 2014-12-18

Clinical Features and Expressions of Foxp3 and IL-17 in Type 1 Autoimmune Pancreatitis in China

Li-Na Zhao, Wen-Ya Han, Lu Lu, Tao Yu, Jie-Yao Li, Xiao-Hui Min, Zhong-Sheng Xia, Yu-Hong Yuan, Qi-Kui Chen

(Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China (mainland))

Med Sci Monit 2014; 20:2720-2728

DOI: 10.12659/MSM.891221


Background: Autoimmune pancreatitis (AIP) is a distinct type of pancreatitis associated with a presumed autoimmune mechanism. The aim of this study was to analyze the clinical features and expressions of forkhead box P3 (Foxp3) and interleukin-17 (IL-17) in type 1 AIP in China and to identify factors for differentiation of AIP from non-AIP chronic pancreatitis (CP).
Material and Methods: We retrospectively reviewed pancreatic specimens with diagnosis of type 1 AIP and non-AIP CP at Sun Yat-Sen Memorial Hospital in China from January 2000 to December 2013. The clinical symptoms, serological data, imaging findings, histopathology, and immunohistochemical findings of Foxp3 and IL-17 in the 2 groups were analyzed.
Results: Twenty-nine patients with type 1 AIP and 20 patients with non-AIP CP were enrolled. Obstructive jaundice was more common in type 1 AIP than in non-AIP CP (62.1% vs. 30.0%, P=0.042). The diffuse or segmental enlargement of the pancreas was more frequent in type 1 AIP than in non-AIP CP (72.4% vs. 40.0%, P=0.038). Histopathology of type 1 AIP presented dense lymphoplasmacytic infiltration, “snowstorm-like” fibrosis and abundant immunoglobulin (Ig) G4+ cells. Foxp3+ cells were more frequently observed in type 1 AIP than in non-AIP CP. IL-17+ cell infiltration was similar between the 2 groups. Furthermore, a positive correlation was found between Foxp3+ and IgG4+ cell counts in the pancreas of patients with type 1 AIP.
Conclusions: Type 1 AIP has dis... read more

Keywords: Forkhead Transcription Factors, Immunoglobulin G, Interleukin-17, Pancreatitis, Pancreatitis, Chronic




Published: 2014-12-18

Low-Dose Intramuscular Dexmedetomidine as Premedication: A Randomized Controlled Trial


Yang Sun, Chaolei Liu, Yuehong Zhang, Bin Luo, Shouzhang She, Lixin Xu, Xiangcai Ruan

Med Sci Monit 2014; 20:2714-2719

DOI: 10.12659/MSM.891051

Published: 2014-12-17

Proteomic Profile in Glomeruli of Type-2 Diabetic KKAy Mice using 2-Dimensional Differential Gel Electrop...


Xiaodan Liu, Gang Yang, Qiuling Fan, Lining Wang

Med Sci Monit 2014; 20:2705-2713

DOI: 10.12659/MSM.893078