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Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to... read more


Published: 2014-10-31

Blocking HIF-1α Following Radiotherapy to Prolong and Enhance the Immune Effects of Radiotherapy: A Hypothesis

Luo Wei, Ge Wei, Song Jin, Chen Cong, Xu Huilin, Ming Pingpo

(Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland))

Med Sci Monit 2014; 20:2106-2108

DOI: 10.12659/MSM.891048


Abstract: Tumor local immune escape is one of the “hallmarks” of cancer leading to poor prognosis. The effects of local radiotherapy on tumors are rapidly emerging as opportunities to remodel and enhance immunity against cancer. However, this immunity remodeling and enhancing are not permanent after local radiotherapy. High expression of HIF-1α following local radiotherapy for tumor cell reoxygenation has been confirmed, and recently accumulating evidence shows the tumor immune suppression effects. These research findings suggest a new direction in the investigation of methods to enhance the efficacy of local radiotherapy. We speculate that by blocking HIF-1α, the immune effects of radiotherapy might be prolonged and enhanced.

Keywords: Hypoxia-Inducible Factor 1, alpha Subunit, Immunity, Active, Radiotherapy



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