Published: 2015-11-30

Low LKB1 Expression Results in Unfavorable Prognosis in Prostate Cancer Patients

Jianlei Lu, Peng Sun, Beibei Sun, Chao Wang

(Department of Urology, The First people’s Hospital of Jining, Jining, Shandong, China (mainland))

Med Sci Monit 2015; 21:3722-3727

DOI: 10.12659/MSM.894847

BACKGROUND: The present study aimed to compare the expression of liver kinase B1 (LKB1) in prostate cancer (PCa) tissues and the paired adjacent tissues, then to evaluate the statistical relationship between LKB1 expression and prognosis of PCa patients.
MATERIAL AND METHODS: The relative expression of LKB1 at mRNA level was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The expression of LKB1 at protein level was measured by immunohistochemistry (IHC) method. The relationship between LKB1 expression and clinicopathologic characteristics was estimated by chi-square test. Kaplan-Meier method was used to analyze the overall survival of PCa patients with different LKB1 expression. Cox regression analysis was performed to estimate the significance of LKB1 expression and clinicopathologic characteristics in the prognosis of PCa patients.
RESULTS: The relative expression of LKB1 at mRNA level was significantly lower in PCa tissues than in the normal tissues (P<0.001). The LKB1 expression was proved to be affected by clinical stage (P=0.019) and PSA concentration (P=0.031) of PCa patients. Moreover, patients with negative LKB1 expression had shorter survival t... read more

Keywords: Prognosis, Prostatic Neoplasms, Vascular Endothelial Growth Factor Receptor-2

Published: 2015-11-29

Evaluation of Temperature and Stress Distribution on 2 Different Post Systems Using 3-Dimensional Finite ...

Yalçın Değer, Özkan Adigüzel, Senem Yiğit Özer, Sadullah Kaya, Zelal Seyfioğlu Polat, Bejna Bozyel

Med Sci Monit 2015; 21:3716-3172

DOI: 10.12659/MSM.896132

Published: 2015-11-29

Efficacy of Ligustrazine Injection as Adjunctive Therapy for Angina Pectoris: A Systematic Review and Met...

Huikai Shao, Lingguo Zhao, Fuchao Chen, Shengbo Zeng, Shengquan Liu, Jiajia Li

Med Sci Monit 2015; 21:3704-3715

DOI: 10.12659/MSM.895362