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Published: 2016-02-13

Gene Polymorphism Association with Type 2 Diabetes and Related Gene-Gene and Gene-Environment Interactions in a Uyghur Population

Shan Xiao, Xiaoyun Zeng, Yong Fan, Yinxia Su, Qi Ma, Jun Zhu, Hua Yao

(Department of Endocrinology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi , China (mainland))

Med Sci Monit 2016; 22:474-487

DOI: 10.12659/MSM.895347


BACKGROUND: We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO) with type 2 diabetes (T2D) in a Uyghur population.
MATERIAL AND METHODS: A case-control study of 879 Uyghur patients with T2D and 895 non-diabetic Uyghur controls was conducted at the Hospital of Xinjiang Medical University between 2010 and 2013. Eight SNPs in CDKAL1, CDKN2A/2B and FTO were analyzed using Sequenom MassARRAY®SNP genotyping. Factors associated with T2D were assessed by logistic regression analyses. Gene-gene and gene-environment interactions were analyzed by generalized multifactor dimensionality reduction.
RESULTS: Genotype distributions of rs10811661 (CDKN2A/2B), rs7195539, rs8050136, and rs9939609 (FTO) and allele frequencies of rs8050136 and rs9939609 differed significantly between diabetes and control groups (all P<0.05). While rs10811661, rs8050136, and rs9939609 were eliminated after adjusting for covariates (P>0.05), rs7195539 distribution differed significantly in co-dominant and dominant models (P<0.05). In gene-gene interaction analysis, after adjusting for covariates the two-locus rs10811661-rs7195539 interaction model had a cross-validation consistency of 10/10 and the highest balanced accuracy of 0.5483 (read more

Keywords: Diabetes Mellitus, Type 2, Genes, p16, Multifactor Dimensionality Reduction, Polymorphism, Genetic




Published: 2016-02-12

Effects of Fentanyl and Morphine on Shivering During Spinal Anesthesia in Patients Undergoing Endovenous ...


Didem Onk, Tülin Akarsu Ayazoğlu, Ufuk Kuyrukluyıldız, Mehmet Aksüt, Zehra Bedir, İlke Küpeli, Oruç Alper Onk, Ayşin Alagöl

Med Sci Monit 2016; 22:469-473

DOI: 10.12659/MSM.897256

Published: 2016-02-12

Identification of Molecular Targets for Predicting Colon Adenocarcinoma


Yansheng Wang, Jun Zhang, Li Li, Xin Xu, Yong Zhang, Zhaowei Teng, Feihu Wu

Med Sci Monit 2016; 22:460-468

DOI: 10.12659/MSM.895881