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Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to the... read more


Published: 2014-09-30

Correlation of PCSK9 Gene Polymorphism with Cerebral Ischemic Stroke in Xinjiang Han and Uygur Populations

Dengfeng Han, Jianhua Ma, Xiaoning Zhang, Jian Cai, Jinlan Li, Tuerhong Tuerxun, Chenguang Hao, Lei Du, Jing Lei

(Department of Neurology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China (mainland))

Med Sci Monit 2014; 20:1758-1767

DOI: 10.12659/MSM.892091


Background: Cerebral ischemic stroke (CIS) is a major cause of morbidity and mortality. Its main pathological basis is atherosclerosis (AS); in turn, the main risk factor in AS is dyslipidemia. Human proprotein convertase subtilisin/kexin9 (PCSK9) plays a key role in regulating plasma low-density lipoprotein (LDL) cholesterol levels. We sought to assess the association between PCSK9 and CIS in Chinese Han and Uygur populations.
Material and Methods: We selected 408 CIS patients and 348 control subjects and used a single-base terminal extension (SNaPshot) method to detect the genotypes of the 20 single-nucleotide polymorphisms (SNPs) in PCSK9.
Results: Distribution of SNP8 (rs529787) genotypes showed a significant difference between CIS and control participants (P=0.049). However, when analyzing Han and Uygur populations separately, we found that only Han subjects showed distribution of SNP1 (rs1711503), SNP2 (rs2479408), and SNP8 (rs529787) alleles that was significantly different between CIS and control participants (P=0.028, P=0.013, P=0.006, respectively), and distribution of SNP2 (rs2479408) in the dominant model (CC vs. CG + GG) was significantly different between CIS and control participants (P=0.013), even after adjustment for covariates (OR: 75.262, 95% confidence interval [CI]: 7.232–783.278, P<0.001). Distribution of the 2 haplotypes (A-C and G-C) (rs1711503 and rs2479408) was significantly different between CIS and control participants (both, P=0.011).
Conclusions: Both rs1711503 and rs2479408 of PCSK9 genes were associated with CIS in the Han population of China. A-C haplotype may be a genetic marker of C... read more

Keywords: atherosclerosis, Ethnic Groups, Ischemic Attack, Transient, Proprotein Convertases




Published: 2014-09-29

Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2 Gene is Not Associated with Stroke Risk in Han Popu...


Yanmin Song, Yinxi Long, Lili Long, Ning Zhang, Yunhai Liu

Med Sci Monit 2014; 20:1751-1757

DOI: 10.12659/MSM.892226

Published: 2014-09-28

Gene Polymorphisms of Adducin GLY460TRP, ACE I/D, AND AGT M235T in Pediatric Hypertension Patients


İbrahim Kaplan, Enver Sancaktar, Aydın Ece, Velat Şen, Nilgün Tekkeşin, Mustafa Kemal Basarali, Selvi Kelekci, Osman Evliyaoglu

Med Sci Monit 2014; 20:1745-1750

DOI: 10.12659/MSM.892140