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eISSN: 1643-3750


Published: 2017-07-21

Malignancy Rates of Thyroid Cytology: Cyst Fluid Benign or Non-Diagnostic?

Güven Güney, İbrahim Tayfun Şahiner

(Department of Pathology, Hitit University School of Medicine, Corum, Turkey)

Med Sci Monit 2017; 23:3556-3561

DOI: 10.12659/MSM.905718


BACKGROUND: We sought to investigate subgroup distribution using Bethesda classification and risks for malignancy. We also compared the malignancy risk of cases that were denoted as non-diagnostic due to cystic contents, with cases that were denoted as non-diagnostic due to presence of other features.
MATERIAL AND METHODS: The study included pathology test results of 1,440 thyroid nodule samples diagnosed using Bethesda classification. Results of 305 thyroidectomy excision specimens from these patients were also compared with cytology results to determine the frequency of malignancy. The non-diagnostic group was divided into two categories: those with cystic contents, and others. Malignancy rates were separately calculated for the two groups, and compared with the other classification groups.
RESULTS: Distribution of malignancy rates by Bethesda classification were as follows: non-diagnostic 12.5% (6/48), benign 1.5% (3/198), atypia of undetermined significance/follicular lesion of undetermined significance (AFLUS) 9% (1/11), suspicious for follicular neoplasm (SFN) 37.5% (3/8), suspicious malignancy 70% (8/26), malignancy 100% (14/14).
CONCLUSIONS: Despite the limited number of cases, our study concluded that cystic content was closer to the benign category than the non-diagnostic category if the assessment was based on malignancy rates. In this group, similar to aspirations containing plenty of lymphocytes that indicates colloid or lymphocytic thyroiditis, it is still controversial whether criterion for adequacy of follicular epithelial cells should be sought, or if they should be regarded as benign in order to prevent unnecessarily performance of repeat aspirations.

Keywords: Biopsy, Fine-Needle, Cyst Fluid, Thyroid Neoplasms, Thyroid Nodule




Published: 2017-07-20

Association Between Diabetes Mellitus and Outcomes of Patients with Sepsis: A Meta-Analysis


Zhiwei Wang, Jianan Ren, Gefei Wang, Qinjie Liu, Kun Guo, Jieshou Li

Med Sci Monit 2017; 23:3546-3555

DOI: 10.12659/MSM.903144

Published: 2017-07-20

Effects of Zinc Finger Protein A20 on Lipopolysaccharide (LPS)-Induced Pulmonary Inflammation/Anti-Inflam...


Ding-Qian Wu, Hong-Bo Wu, Mao Zhang, Jian-An Wang

Med Sci Monit 2017; 23:3536-3545

DOI: 10.12659/MSM.901700