Published: 2015-07-02

Survival after Gastrectomy in Node-Negative Gastric Cancer: A Review and Meta-Analysis of Prognostic Factors

Yanming Zhou, Feng Yu, Lupeng Wu, Feng Ye, Leilei Zhang, Yumin Li

(Department of Hepato-Biliary-Pancreato-Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China (mainland))

Med Sci Monit 2015; 21:1911-1919

DOI: 10.12659/MSM.893856

BACKGROUND: Lymph node metastasis is one of the most important prognostic factors for survival of patients with gastric cancer (GC) after surgical resection. Nevertheless, a considerable number of patients have node-negative disease. We performed the present systematic review to evaluate survival and identify prognostic factors in node-negative GC patients undergoing curative intent resection.
MATERIAL AND METHODS: Relevant studies published between January 2000 and January 2015 were identified by searching the PubMed database and reviewed systematically. Summary relative risks (RR) and 95% confidence intervals (95% CI) were estimated using random-effects models.
RESULTS: Thirty observational studies involving 12 504 patients were included in the review. Median 5-year overall survival was 84.3% (range, 53–96.3%). Pooled analysis showed that old age (RR, 1.26; 95%CI, 1.13–1.42), <D2 lymph node dissection (1.28; 1.05–1.55), larger tumor (1.18; 1.10–1.26), serosal invasion (2.03; 1.68–2.44), lymphatic invasion (1.25; 1.00–1.57), vascular invasion (1.67; 1.19–2.34), and lymphovascular invasion (1.93; 1.20–3.10) were significant association with decreased survival.
CONCLUSIONS: Surgical resection offers good overall survival for patients with node-negative GC. Tumor-related factors seem to have most prognostic significance.

Keywords: Meta-Analysis as Topic, Stomach Neoplasms, Survival Rate

Published: 2015-07-01

Delays in Motor Development in Children with Down Syndrome

Roksana Malak, Anna Kostiukow, Agnieszka Krawczyk-Wasielewska, Ewa Mojs, Włodzimierz Samborski

Med Sci Monit 2015; 21:1904-1910

DOI: 10.12659/MSM.893377

Published: 2015-07-01

Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies

Wen-Qing Lian, Fei Luo, Xian-Lu Song, Yong-Jie Lu, Shan-Chao Zhao

Med Sci Monit 2015; 21:1895-1903

DOI: 10.12659/MSM.893579