Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to... read more

Published: 2014-10-20

Disrupting the Balance between Tumor Epithelia and Stroma is a Possible Therapeutic Approach for Pancreatic Cancer

Zheng Wang, Jiahui Li, Xin Chen, Wanxing Duan, Qingyong Ma, Xuqi Li

(Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi, China (mainland))

Med Sci Monit 2014; 20:2002-2006

DOI: 10.12659/MSM.892523

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a type of highly lethal malignant tumor. PDAC is locally invasive and is surrounded by a dense desmoplasia or fibrosis, which can involve adjacent vital structures. Previously, the effect of pancreatic stellate cells (PSCs) of stroma in the progression of PDAC has received more attention, and most in vitro and in vivo studies revealed that PSCs appear to confer biological aggressiveness. However, clinical trials targeting desmoplasia or PSCs showed disappointing results. Recent studies found that stromal components, especially activated PSCs, are able to inhibit the occurrence and progression of PDAC. Inhibition of the stroma or desmoplasia through genetic regulations or drugs accelerates the formation and progression of PDAC. Thus, we hypothesized that in various times and spaces, there is a balance between the tumor epithelia and stroma; once the balance is upset, the tumor traits may undergo certain changes. Therefore, finding the key changing points of this relationship to corrupt or influence it, instead of blindly inhibiting the stroma motivation or simply maintaining stroma activation, will destroy the cooperation or promote the competition and antagonism among cells. This approach may render tumors more vulnerable and thus unable to resist anti-cancer therapies.

Keywords: Hedgehog Proteins, Pancreatic Neoplasms, pancreatic stellate cells, Stromal Cells, tumor microenvironment

Published: 2014-10-20

Effect of Orthodontic Debonding and Adhesive Removal on the Enamel – Current Knowledge and Future Persp...

Joanna Janiszewska-Olszowska, Tomasz Szatkiewicz, Robert Tomkowski, Katarzyna Tandecka, Katarzyna Grocholewicz

Med Sci Monit 2014; 20:1991-2001

DOI: 10.12659/MSM.890912

Published: 2014-10-19

Carvacrol and Pomegranate Extract in Treating Methotrexate-Induced Lung Oxidative Injury in Rats

Hadice Selimoğlu Şen, Velat Şen, Mehtap Bozkurt, Gül Türkçü, Abdulmenap Güzel, Cengizhan Sezgi, Özlem Abakay, Ibrahim Kaplan

Med Sci Monit 2014; 20:1983-1990

DOI: 10.12659/MSM.890972