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Published: 2015-03-02

Factors Related to Long-Term Post-Stroke Cognitive Impairment in Young Adult Ischemic Stroke

Ying Huang, Shanshan Yang, Jianping Jia

(Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China (mainland))

Med Sci Monit 2015; 21:654-660

DOI: 10.12659/MSM.892554


Background: Post-stroke cognitive impairment is common and a decisive prognostic factor. However, few studies have reported on post-stroke cognition in young adults, especially long-term cognition. This study was designed to investigate the influence of baseline factors, treatments, and functional outcome on the long-term cognitive outcome in young adults with ischemic stroke.
Material and Methods: Consecutive patients aged 18–45 years between January 1, 2006 and December 31, 2010, with a first-ever ischemic stroke, were recruited for cognitive assessment by telephone from December 10 to December 31, 2013 using modified versions of “Telephone Instrument for Cognitive Status” (TICS-m) scale. The relationship of cognitive impairment with baseline factors, treatments, and functional outcome were evaluated.
Results: A total of 350 patients with an average age of 41.0±6.8 years (69.7% males and 30.3% females) were reviewed. The average follow-up period was 5.8±3.2 years, and cognitive impairment existed in 39.4% of patients at follow-up. Stroke severity on admission, functional outcome (modified Rankin Scale, mRS >2) at discharge, left anterior circulation syndrome, and stroke recurrence were markedly associated with post-stroke cognitive impairment (all P<0.01). Post-stroke cognition was also significantly related to mRS at follow-up (r=–0.563, P<0.001).

Conclusions: Post-stroke cognition was related to functional outcome: hence, treatment directed toward reducing functional disability might also reduce cognitive impairment.

Keywords: Adult, Hypoxia-Ischemia, Brain, mild cognitive impairment




Published: 2015-03-01

Performance of Screening Tools in Detecting Major Depressive Disorder among Patients with Coronary Heart ...


Yanping Ren, Hui Yang, Colette Browning, Shane Thomas, Meiyan Liu

Med Sci Monit 2015; 21:646-653

DOI: 10.12659/MSM.892537

Published: 2015-02-28

The Prognostic Significance of Src and p-Src Expression in Patients with Osteosarcoma


Chao Hu, Zhouming Deng, Yi Zhang, Lei Yan, Lin Cai, Jun Lei, Yuanlong Xie

Med Sci Monit 2015; 21:638-645

DOI: 10.12659/MSM.892803