Logo





Published: 2014-09-16

Polymorphism of ABCB1/MDR1 C3435T in Children and Adolescents with Partial Epilepsy is due to Different Criteria for Drug Resistance – Preliminary Results

Ewa Emich-Widera, Wirginia Likus, Beata Kazek, Aleksander L. Sieroń, Ksymena Urbanek

(Department of Neuropediatrics, School of Medicine, Medical University of Silesia, Katowice, Poland)

Med Sci Monit 2014; 20:1654-1661

DOI: 10.12659/MSM.890633


Background: The diagnosis of “drug resistance” in epilepsy can be defined and interpreted in various ways. This may be due to discrepant definitions of drug resistance to pharmacotherapy.
The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different criteria for qualification to groups sensitive and resistant to applied pharmacotherapy.
Material and Methods: Evaluation of C3435T polymorphism of MDR1/ABCB1 gene was conducted on a group of 82 white children and young adolescents up to 18 years old. While qualifying the patients to the group of sensitive or drug resistant, the following 4 definitions of drug resistance were applied: the ILAE’s, Appleton’s, Siddiqui’s, and Berg’s.
Results: A detailed analysis of genotypes of the MDR1 gene did not show any significant discrepancies between the groups of patients resistant and sensitive to antiepileptic drugs (AEDs) in 4 consecutive comparisons taking into consideration various criteria of sensitivity and resistance to pharmacotherapy.
Conclusions: The obtained results clearly confirm the lack of a connection between the occurrence of drug-resistant epilepsy and C435T polymorphism of the MDR1 gene irrespective of the definition of drug resistance applied to the patient.

Keywords: Adolescent, Child, Epilepsies, Partial, Genes, MDR, Patient Selection



Related Articles (0)

Coming Soon...

Published: 2014-09-15

The Incidence and Risk Factors of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants...


Ali Riza Cenk Celebi, Ikbal Seza Petricli, Emre Hekimoglu, Nihal Demirel, Ahmet Yagmur Bas

Med Sci Monit 2014; 20:1647-1653

DOI: 10.12659/MSM.892262

Published: 2014-09-14

What is the Lowest Value of Left Ventricular Baseline Ejection Fraction that Predicts Response to Cardiac...


Aysen Agacdiken Agir, Umut Celikyurt, Tayfun Sahin, Irem Yılmaz, Kurtulus Karauzum, Serdar Bozyel, Dilek Ural, Ahmet Vural

Med Sci Monit 2014; 20:1641-1646

DOI: 10.12659/MSM.891036