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Published: 2015-07-04

Comparison of T1ρ and T2* Relaxation Mapping in Patients with Different Grades of Disc Degeneration at 3T MR

Xinjuan Zhang, Li Yang, Fei Gao, Zhenguo Yuan, Xiangtao Lin, Bin Yao, Weibo Chen, Queenie Chan, Guangbin Wang

(Department of Radiology, Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong, China (mainland))

Med Sci Monit 2015; 21:1934-1941

ID: 894406


BACKGROUND: T1ρ and T2* relaxation times are capable of providing information about early biochemical changes in intervertebral disk degeneration (IVDD). The purpose of this study was to assess and compare T1ρ and T2* mapping in IVDD with reference to Pfirrmann grade.
MATERIAL AND METHODS: Lumbar sagittal T2-weighted, T1ρ and T2* relaxation MRI were performed at 3.0T in 42 subjects covering discs L1–L2 to L5–S1. All the discs were morphologically assessed according to the Pfirrmann grade. Regions of interest (ROIs) were drawn over the T1ρ and T2*mappings, including nucleus pulposus (NP) and annulus fibrosus (AF). Wilcoxon signed rank test, Kruskal-Wallis test, and Spearman rank correlation were performed.
RESULTS: The difference in T1ρ and T2* values between NP and AF were highly significant (P<0.001). The trends of decreasing T1ρ and T2* values of both NP and AF with increasing Pfirrmann grades was significant (P<0.01), particularly between Pfirrmann grade II and III (P<0.001), whereas T2* mapping was additionally able to detect changes in the AF between Pfirrmann grade I and II (P<0.05). Pfirrmann grades were inversely significantly correlated with both T1ρ and T2* values in the NP (r=–0.69, P<0.001; r=–0.56, P<0.001) and AF (r=–0.45, P<0.001; r=–0.26, P<0.001).
CONCLUSIONS: ... read more

Keywords: Early Diagnosis, intervertebral disc degeneration, Lumbar Vertebrae, Magnetic Resonance Imaging




Published: 2015-07-03

RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Child...


Yang Yu, Yuanjun Hu, Kaisheng Li, Zhihong Chen, Hongmei Zhang, Lei Zhang

Med Sci Monit 2015; 21:1928-1933

ID: 893606

Published: 2015-07-03

Distinctive Effect of Donepezil Treatment on P300 and N200 Subcomponents of Auditory Event-Related Evoked...


Arūnas Vaitkevičius, Gintaras Kaubrys, Eglė Audronytė

Med Sci Monit 2015; 21:1920-1927

DOI: 10.12659/MSM.894940