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Published: 2014-09-01

Association Between GSTM1 Null Genotype and Coronary Artery Disease Risk: A Meta-Analysis

Mei Yang, Jing Zhao, Lin Xing, Li Shi

(Intensive Care Unit, Jinan Third People’s Hospital, Jinan, China (mainland))

Med Sci Monit 2014; 20:1550-1555

DOI: 10.12659/MSM.890876


Background: We conducted a meta-analysis to assess the association between polymorphisms of GSTM1 null genotype and coronary artery disease (CAD) risk.
Material and Methods: Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) were retrieved before March 2014. All studies reporting adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of CAD risk were included.
Results: A total of 13 case-control studies, including 5453 cases and 5068 controls, were collected. There was a significant association between GSTM1 null genotype and CAD risk (adjusted OR=1.26; 95% CI, 1.11–1.43; I^2=3%). When stratified by ethnicity, a significantly elevated risk was observed in whites. In the subgroup analysis according to disease type, a significantly increased myocardial infarction (MI) risk was observed. Subgroup analysis of smoking status showed an increased CAD risk in smokers.
Conclusions: Our results indicate that GSTM1 null genotype is associated with an increased CAD risk.

Keywords: Coronary Artery Disease, Glutathione Transferase, Meta-Analysis as Topic, Polymorphism, Genetic




Published: 2014-08-30

Efficacy of Surgical Resection for Pulmonary Metastases from Hepatocellular Carcinoma


Yan-Ming Zhou, Xiao-Feng Zhang, Feng Yu, Xiao-Bin Liu, Lu-Peng Wu, Bin Li, Jia-Mei Yang

Med Sci Monit 2014; 20:1544-1549

DOI: 10.12659/MSM.890853

Published: 2014-08-29

Deterioration of Heart Rate Recovery Index in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)


Olcay Ozveren, Orhan Dogdu, Cihan Sengul, Veysel Cinar, Elif Eroglu, Zekeriya Kucukdurmaz, Muzaffer Degertekin

Med Sci Monit 2014; 20:1539-1543

DOI: 10.12659/MSM.890741