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Published: 2016-07-30

Post-Irradiation Bladder Syndrome After Radiotherapy of Malignant Neoplasm of Small Pelvis Organs: An Observational, Non-Interventional Clinical Study Assessing VESIcare®/Solifenacin Treatment Results

Janusz Jaszczyński, Zbigniew Kojs, Andrzej Stelmach, Łukasz Wohadło, Elzbieta Łuczyńska, Sylwia Heinze, Janusz Rys, Jerzy Jakubowicz, Piotr Chłosta

(Department of Urology, Center of Oncology Maria Skłodowska-Curie Memorial Institute, Cracow Branch, Cracow, Poland)

Med Sci Monit 2016; 22:2691-2698

DOI: 10.12659/MSM.899327


BACKGROUND: Radiotherapy is explicitly indicated as one of the excluding factors in diagnosing overactive bladder syndrome (OAB). Nevertheless, symptoms of OAB such as urgent episodes, incontinence, pollakiuria, and nocturia, which are consequences of irradiation, led us to test the effectiveness of VESIcare®/Solifenacin in patients demonstrating these symptoms after radiation therapy of small pelvis organs due to malignant neoplasm.
MATERIAL AND METHODS: We conducted an observatory clinical study including 300 consecutive patients with symptoms of post-irradiation bladder; 271 of those patients completed the study. The observation time was 6 months and consisted of 3 consecutive visits taking place at 12-week intervals. We used VESIcare® at a dose of 5 mg a day. Every sixth patient was examined urodynamically at the beginning and at the end of the observation period, with an inflow speed of 50 ml/s.
RESULTS: We noticed improvement and decline in the average number of episodes a day in the following parameters: number of micturitions a day (–36%, P<0.01), nocturia (–50%, P<0.01), urgent episodes (–41%, P<0.03), and episodes of incontinence (–43%, P<0.01). The patients’ quality of life improved. The average maximal cystometric volume increased by 34 ml (21%, p<0.01), average bladder volume of “first desire” increased by 42 ml (49%, P<0.01), and average detrusor muscle pressure at maximal cystometric volume diminished by 9 cmH2O (–36%, P<0.03).
CONCLUSIONS: The substance is well-tolerated. Solifenacin administered long-term to patients with symptoms of OAB after radiotherapy of a malignant neoplasm of... read more

Keywords: Muscarinic Antagonists, Urinary Bladder Neoplasms, Urodynamics




Published: 2016-07-29

Effect of Mir-122 on Human Cholangiocarcinoma Proliferation, Invasion, and Apoptosis Through P53 Expressi...


Cuiping Wu, Jinmei Zhang, Xiangang Cao, Qian Yang, Dequan Xia

Med Sci Monit 2016; 22:2685-2690

DOI: 10.12659/MSM.896404

Published: 2016-07-29

Upregulation of Transient Receptor Potential Canonical Channels Contributes to Endotoxin-Induced Pulmonar...


Gui-Lan Chen, Hongni Jiang, Fangdong Zou

Med Sci Monit 2016; 22:2679-2684

DOI: 10.12659/MSM.898111