Xu-Juan Li, Zhi-Yuan Dai, Bei-Ying Zhu, Jia-Ping Zhen, Wen-Fu Yang, De-Qiang Li
(Department of Psychiatry, First Affiliated Hospital of Zhejiang University, Hangzhou, China (mainland))
Med Sci Monit 2014; 20:1267-1273
The aim of this study was to investigate effects of the antidepressant sertraline on executive function and quality of life in patients with advanced cancer.
Material and Methods: We assigned 122 patients with stage III or IV cancer to the depressed group (DG, n=86) or the non-depressed group (NG, n=36). All subjects were given supportive treatment and patients in the DG received additional antidepressant treatment.
Results: There were significant differences in total scores of the Hamilton anxiety scale (HAMA) and the Hamilton depression scale (HAMD), performance in the Wisconsin card sorting test, and SF-36 domains. After antidepressant treatment, the level of depression and anxiety decreased significantly in the DG, but was still significantly higher than in the NG....
Keywords: Depression, executive function, Pain Clinics, Quality of Life