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Published: 2014-07-22

Effects of Sertraline on Executive Function and Quality of Life in Patients with Advanced Cancer

Xu-Juan Li, Zhi-Yuan Dai, Bei-Ying Zhu, Jia-Ping Zhen, Wen-Fu Yang, De-Qiang Li

(Department of Psychiatry, First Affiliated Hospital of Zhejiang University, Hangzhou, China (mainland))

Med Sci Monit 2014; 20:1267-1273

DOI: 10.12659/MSM.890575


Background: The aim of this study was to investigate effects of the antidepressant sertraline on executive function and quality of life in patients with advanced cancer.
Material and Methods: We assigned 122 patients with stage III or IV cancer to the depressed group (DG, n=86) or the non-depressed group (NG, n=36). All subjects were given supportive treatment and patients in the DG received additional antidepressant treatment.
Results: There were significant differences in total scores of the Hamilton anxiety scale (HAMA) and the Hamilton depression scale (HAMD), performance in the Wisconsin card sorting test, and SF-36 domains. After antidepressant treatment, the level of depression and anxiety decreased significantly in the DG, but was still significantly higher than in the NG....

Keywords: Depression, executive function, Pain Clinics, Quality of Life




Published: 2014-07-21

Application of fasciocutaneous V-Y advancement flap in primary and recurrent sacrococcygeal pilonidal sin...


Ismail Demiryilmaz, Ismail Yilmaz, Kemal Peker, Fehmi Celebi, Orhan Cimen, Arda Isik, Senol Bicer, Deniz Firat

Med Sci Monit 2014; 20:1263-1266

DOI: 10.12659/MSM.890752

Published: 2014-07-20

Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal c...


Dinç Süren, Mustafa Yıldırım, Vildan Kaya, Arsenal Sezgin Alikanoğlu, Nurullah Bülbüller, Mustafa Yıldız, Cem Sezer

Med Sci Monit 2014; 20:1255-1262

DOI: 10.12659/MSM.890598