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Published: 2015-04-01

Effects of Long-term Exercise on Spatial Learning, Memory Ability, and Cortical Capillaries in Aged Rats

Sanrong Wang, Lin Chen, Lei Zhang, Chunxia Huang, Yun Xiu, Feifei Wang, Chunni Zhou, Yanmin Luo, Qian Xiao, Yong Tang

(Department of Histology and Embryology, Chongqing Medical University, Chongqing, China (mainland))

Med Sci Monit 2015; 21:945-954

DOI: 10.12659/MSM.893935


BACKGROUND: This study aimed to determine the effects of long-term running exercise on spatial learning, spatial memory, and cortical capillaries in aged rats.
MATERIAL AND METHODS: Fourteen-month-old female and male Sprague-Dawley rats were randomly divided into an exercised group (EG) and a non-exercised group (NG). The EG rats were trained on treadmill running for 4 or 14 months. The NG rats were housed under identical conditions without running. Spatial learning and memory were assessed with the Morris water maze. The cortical capillary parameters were quantitatively investigated using immunohistochemical and stereological methods.
RESULTS: The escaped latencies of the EG were significantly different from those of the NG in 18-month-old females and 28-month-old males (p<0.05). However, 28-month-old females and 18-month-old males showed no differences in escape latency between the EG and NG (p>0.05). In 28-month-old female rats, stereological techniques showed significant differences between the EG and NG in the cortical capillary volume (median, 22.55 vs. 11.42, p<0.05) and the cortical capillary surface area (median, 7474.13 vs. 3935.90, p<0.05). In 28-month-old male rats, the EG had a significantly longer total cortical capillary length (median, 530.35 vs. 156.27, p<0.05), significantly larger cortical capillary volume (median, 16.47 vs. 3.65, p<0.01), and a significantly larger cortical capillary total surface area (median, 7885.79 ... read more

Keywords: Cerebral Cortex, Exercise, Spatial Behavior




Published: 2015-03-31

Comparison of Apical Microleakage of Dual-Curing Resin Cements with Fluid-Filtration and Dye Extraction T...


Sadullah Kaya, Senem Yiğit Özer, Özkan Adigüzel, Hasan Oruçoğlu, Yalçın Değer, Emin Caner Tümen, İbrahim Uysal

Med Sci Monit 2015; 21:937-944

DOI: 10.12659/MSM.892741

Published: 2015-03-30

Insulin Use and Risk of Diabetic Macular Edema in Diabetes Mellitus: A Systemic Review and Meta-Analysis ...


Jun Zhang, Jingxue Ma, Nalei Zhou, Bin Zhang, Jianbin An

Med Sci Monit 2015; 21:929-936

DOI: 10.12659/MSM.892056