Medical Science Monitor

Current Volume 20, 2014

Published: 2014-04-16

The root canal system: A channel through which we can seed cells into grafts

Gu Cheng, Zu-Bing Li

Med Sci Monit 2014;20:624-627

DOI: 10.12659/MSM.890057

Abstract: Bone tissue engineering is bringing hope to patients with jawbone defects, but this technology works well only for small- to moderate-sized jawbone defects. For large segmental jawbone defects, it is difficult to form the functional vascular networks within the graft due to limited diffusion of nutrition and uneven distribution of seed cells. From the standpoint of bionics, seed cells should be continuously transmitted into the graft to replace the necrotic cells during the entire process of bones regeneration. However, the existing one-time inoculation method (OIM) fails to achieve this goal because it is almost impossible to re-open the wound and inoculate cells into grafts that have already been implanted into the body. Inspired by the anatomical structure of jawbones,...

Keywords: bone tissue engneering, seed cells, Dental Pulp Cavity


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