Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to... read more

Published: 2014-11-23

Efficacy of Combined Therapy of Periosteum and Bone Allograft in a Critical-Sized Defect Model in New Zealand White Rabbits

Dawei Zhang, Dong Huang, Yongjun Huang, Yuanhang Liu, Bochuan Lin, Chaoqun Yu, Yong Mou, Weichi Wu, Huiru Zhang, Hao Lin

(Department of Traumatic and Microsurgical, The Third Affiliated Hospital of Southern Medical University and Second People’s Hospital of Guangdong Province, Guangzhou, China (mainland))

Med Sci Monit 2014; 20:2394-2403

DOI: 10.12659/MSM.891103

Background: Large segmental bone defects caused by trauma, infection, or bone tumor resection are difficult to cure and have been a problem in the field of bone repair for decades. The objective of this study was to discuss the efficacy of combined therapy of free periosteum and bone allograft in treating bone defects and to provide a theoretical basis for clinical application of this therapy.
Material and Methods: A unilateral tibia cortical defect model in New Zealand white rabbits was established according to Girolamo method. Total 48 rabbits were randomized into 3 groups: a simple bone defect group (n=16), an autogenous bone graft group (n=16), and a periosteum and bone allograft combined therapy group (n=16). The efficacy was evaluated by imaging inspections and scoring, HE staining, and RT-PCR in postoperative weeks 2, 4, 8, and 12.
Results: The results of imaging and histopathological inspections in the study indicated that in postoperative weeks 4, 8, and 12 the experimental and control groups had statistically significant differences in Lane-Sandhu radiographic scoring and relative bone density when compared with the simple bone defect group (P<0.05). The RT-PCR results suggested that the expression of SPP-1, BMP-2, and VEGF in the experimental group was higher than in the control group (P<0.05) and the expression of Col Ia1 in the control group was higher than in the experimental group (P<0.05).
Conclusions: Efficacies of the combined therapy (periosteum combined with bone allografting) and the criterion standard therapy (autogenous bone grafting) are equivalent in treating bone defects in New Zealand w... read more

Keywords: Bone Diseases, Bone Transplantation, Periosteum, Rabbits

Published: 2014-11-22

Central Cannulation by Seldinger Technique: A Reliable Method in Ascending Aorta and Aortic Arch Replacem...

Laszlo Göbölös, Peter Ugocsai, Maik Foltan, Alois Philipp, Andrea Thrum, Szabolcs Miskolczi, Pietro G. Malvindi, Vincenzo di Gregorio, Dimitrios Pousios, Manoraj Navaratnarajah, Sunil K. Ohri

Med Sci Monit 2014; 20:2386-2393

DOI: 10.12659/MSM.890813

Published: 2014-11-22

Aberrant Methylation of PCDH8 is a Potential Prognostic Biomarker for Patients with Clear Cell Renal Cell...

Ying-Li Lin, Yan-Ling Wang, Xing-Li Fu, Jian-Guo Ma

Med Sci Monit 2014; 20:2380-2385

DOI: 10.12659/MSM.892433