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06 August 2016 : Clinical Research  

Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade

Linghua LiuBE, Ruokun HuangC, Dezhang MaD, Wenjun ChengF, Wei FengF, Danmou XingD, Wusheng KanC, Zhihong XiaoAG

DOI: 10.12659/MSM.896987

Med Sci Monit 2016; 22:2775-2778

Abstract

BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA).

MATERIAL AND METHODS: We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system.

RESULTS: Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades.

CONCLUSIONS: Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA.

Keywords: Biomarkers - metabolism, Adrenomedullin - metabolism, Case-Control Studies, Cross-Sectional Studies, Osteoarthritis, Knee - pathology, Severity of Illness Index, Synovial Fluid - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750