03 July 2015 : Clinical Research
RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children
Yang YuABE, Yuanjun HuABE, Kaisheng LiBC, Zhihong ChenCDF, Hongmei ZhangCD, Lei ZhangBCDOI: 10.12659/MSM.893606
Med Sci Monit 2015; 21:1928-1933
Abstract
BACKGROUND: Wilms’ tumor (WT) is the most common malignant renal tumor in children. Previous studies suggested the reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role in numerous human cancers. The current study was done to investigate the associations of RECK single-nucleotide polymorphisms (SNPs) with the WT susceptibility in Chinese children.
MATERIAL AND METHODS: We analyzed 2 SNPs (rs10972727and rs11788747) in a total of 97 WT children and 194 healthy matched controls (1:2 ratio) by real-time PCR and PCR-RFLP genotyping analysis.
RESULTS: We found that the G allele of rs11788747 in the RECK gene was significantly associated with WT in Chinese children (OR=0.7, 95% CI: 0.45–0.99; P=0.042); as with another SNP rs10972727, however, no statistically significant difference was detected. Further analysis showed there was also a statistically significant difference in genotype frequencies between terminal tumor stage (P=0.026) and metastatic groups (P=0.002).
CONCLUSIONS: The present data indicate that there is a significant association between mutant G of rs11788747 in RECK and WT risk. G carriers with advanced tumor stage or with metastasis might have an increased risk of WT.
Keywords: Child, Preschool, Child, Case-Control Studies, GPI-Linked Proteins - genetics, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Wilms Tumor - physiopathology
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