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23 January 2014 : Review article  

Primary cardiac angiosarcoma – a review

Swetal Dilip PatelABCDEF, Ashley PetersonABCDEF, Artur BartczakABCDEF, Sarah LeeABCDEF, Sławomir ChojnowskiABCDEF, Piotr GajewskiABCDEF, Marios LoukasABCDEFG

DOI: 10.12659/MSM.889875

Med Sci Monit 2014; 20:103-109

Abstract

Primary cardiac neoplasms are extremely rare. Angiosarcoma is the most commonly seen histological subtype and is characterized by its permeating and destructive nature. Unfortunately, primary cardiac angiosarcoma is often overlooked as an initial diagnosis because of its rarity. Since the time it was first identified in 1934, little progress has been made in improving survival outcome. Complete or partial surgical resection is still the best option for palliation, with little hope for cure. Improvements have been made in the ability to view and distinguish tumors. Echocardiography is one of the most useful diagnostic tools because of its high sensitivity; therefore, CT and MR images are often used to detect sites of metastatic disease. Immunohistochemistry staining can also be employed as an adjunctive diagnostic tool. CD31, CD34, FLI-1, and von Willebrand factor are the most commonly used markers in detecting tumors of endothelial origin. However, due to the vast heterogeneity within a tumor, immunohistochemistry staining can be quite variable. Surgical resection remains the standard modality of treatment. Primary cardiac angiosarcoma is largely resistant to chemotherapy and/or radiation. However, the exact benefit and its place in a multimodality treatment regimen are still under investigation.

Keywords: Echocardiography, Antigens, CD34 - metabolism, Antigens, CD31 - metabolism, Heart Neoplasms - surgery, Hemangiosarcoma - surgery, Microfilament Proteins - metabolism, Receptors, Cytoplasmic and Nuclear - metabolism, Tumor Markers, Biological - metabolism, von Willebrand Factor - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750