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MicroRNA-328 may contribute to chemoresistance in glioblastoma cancer stem cells by targeting ABCG2

Wei-Qing Li, Yi-Ming Li, Bang-Bao Tao, Yi-Cheng Lu, Guo-Han Hu, Hui-Min Liu, Jin He, Yi Xu, Hong-Yu Yu

Med Sci Monit 2010; 16(10): HY27-30

ID: 881180


ABCG2, which encodes an ATP-binding cassette transporter protein, is associated with the phenotype of cancer stem cells and is used to define the pluripotential side population cells by flow cytometry and slide-cytometry. MicroRNAs control a wide array of biological processes (e.g., cell differentiation, proliferation and apoptosis) whose dysregulation is a hallmark of cancer. MicroRNA-328 (miR-328) is underexpressed in many cancers including glioblastoma multiforme and contributes to tumor resistance to chemotherapy. ABCG2 is associated with multi-drug resistance and is also highly expressed in glioblastoma. Some preliminary studies have shown that ABCG2 is the target gene for miRNA-328. Thus, we hypothesize that modulating ABCG2 expression by targeting miRNA-328 in glioblastoma cancer stem cells could represent a promising strategy for therapeutic manipulation to increase the efficacy of chemotherapeutic agents for glioblastoma, a highly lethal type of cancer.

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