01 August 2009
Age related decline of microvascular regulation measured in healthy individuals by retinal dynamic vessel analysis
Matthias KneserABCDEF, Thomas KohlmannCD, Jens PokornyBF, Frank TostACDGMed Sci Monit 2009; 15(8): CR436-441 :: ID: 878144
Abstract
Background
The present study investigates the regulative retinal vascular answer to flicker as measured by Dynamic Vessel Analysis (DVA) in relation to age.
Material and Method
52 clinically healthy volunteers (age 20-78 years) free of cardiovascular risk factors according to an extensive medical history, lab values and blood pressure (BP) were examined by retinal DVA. The regulative arterial and venous responses to flicker were recorded with a Retinal Vessel Analyzer (Imedos, Jena/Germany).
Results
The retinal arterial regulative amplitude, consisting of a dilation and constriction component, diminished by 45% with age, mainly due to the constricting component diminishing by 75%. The venous response to flicker was unaltered.
Conclusions
The vascular regulative amplitude as well as its constriction part are observable in retinal arteries. They undergo major reduction in healthy individuals during adult lifetime. The results can be explained by the change of biomechanical properties of the vessel wall as well as physiological changes of the vascular endothelial function with age. Hereby the DVA technique shows good potential for investigating cardiovascular aspects in preventive medicine. Whenever doing functional DVA testing these results should be taken in account. The data obtained are first normative age related DVA data.
Keywords: Regression Analysis, Retinal Artery, Microvessels - physiology, Hematology - methods, Health, Retinal Vein, Aging - physiology, Retinal Vessels - physiology, young adult
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952