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Ahmet Alper Kiykim, Gultekin Genctoy, Mehmet Horoz, Sibel Sari, Ebru Gok, Banu Coskun, Nejat Yilmaz, Iclal Gurses
Med Sci Monit 2009; 15(8): CS132-134
Although the exact role of the diphenylhydantoin treatment on the immune system is still unclear, prolonged administration of diphenylhydantoin has been suggested to be associated with immune-based disorders and syndromes.
Material and Method: A case of fibrillary glomerulonephritis associated with DPH treatment is reported. This is the first reported case of fibrillary glomerulonephritis associated with this commonly used common anticonvulsive drug.
Conclusions: A more routine surveillance for proteinuria in patients receiving DPH is recommended.