Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

Analysis of the expression of estrogen and progesteron receptors, and of PCNA and Ki67 proliferation antigens, in uterine myomata cells in relation to the phase of the menstrual cycle

Ryszard Zasławski, Paweł Surowiak, Piotr Dzięgiel, Leonard Prętnik, Maciej Zabel

Med Sci Monit 2001; 7(5): CR908-913 :: ID: 509061

Abstract

Background: The purpose of this study was to provide an immunocytochemical evaluation of the expression of receptors for estrogens (ER) and progesterone (PgR), and of Ki67 and PCNA (proliferating cell nuclear antigen) proliferation antigens in uterine myomata cells in three groups of patients operated in various phases of the menstrual cycle, and to determine the relationship between the expression of the receptors, the proliferative activity of myoma cells, and the phase of the menstrual cycle during which the tumor was excised
Material/Methods: The studies were performed on samples of uterine 85 leiomyomata. Twelve of the patients were operated in the follicular phase of menstrual cycle, 50 in the luteal phase, and 27 in the post-menopausal period. The receptors and proliferating antigens were detected immunocytochemically. The intensity of the immunocytochemical reaction was evaluated using the ImmunoReactive Score (IRS).
Results: In all three groups of patients the expression of PgR significantly exceeded that of ER. Also, in all the patients the mean expression of PCNA significantly exceeded the expression of Ki76.
Conclusions: The expression of the studied antigens did not depend upon the phase of the menstrual cycle, and was similar in the postmenopausal period.

Keywords: uterine myomata, estrogen receptor, progesteron receptor, PCNA, Ki67

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750