03 November 1997
Clinical importnace of the isotype of anticariolipin antibodies in patients with connective tissue diseases
Lidia Ostanek, Irena Fiedorowicz-FabrycyMed Sci Monit 1997; 3(6): CR835-839 :: ID: 501794
Abstract
The purpose of this work was to evaluate the frequency of occurrence of high anticardiolipinic antibody titre (aCL) class IgG and IgM in patients with different systemic connective tissue diseases and determination of the relationship between chosen clinical symptoms and isotype of existing antibodies. 132 patients, including 119 women and 13 men at the age of 20-74 (average age 49.8), with different systemic connective tissue diseases, were examined. Anticardiolipinic antibodies were marked with the use of ELISA method with the application of tests produced by SIGMA. High titres of aCL were found in 35 examined patients (26.5%), in that number 18 (13.6%) were high values of aCL from IgG class, in 11 (9.3%) of aCL from IgM class and in 6 (4.5%) high titres of aCL of both classes (IgG+IgM) Secondary antiphospolipidic anatomosis was diagnosed in 23 patients according to Harris criteria. Skin changes were the most common clinical symptoms and were diagnosed in 17 patients with high titre of aCL. Neurological disturbances were observed in 12 patients, cardiological complications - in 10, thrombosis - in 5. Obstetrical failure occurred in 9 patients. In 23 patients thrombocytopenia occurred, in 10 - leucopenia, in 10 - APTT elongation, in 8 - presence of lupous anticoagulant and in 3 - false positive Wasserman's reactions. Most clinical symptoms, as well as deviations in immunological and haematological examinations, correlated with high class IgG aCL titres.
Keywords: anticardiolipinic antibodies, systemic connective tissue diseases, isotypes IgG and IgM of anticardiolipinic antibodies
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
15 Mar 2024 : Clinical Research
Impact of One-Lung Ventilation on Oxygenation and Ventilation Time in Thoracoscopic Heart Surgery: A Compar...Med Sci Monit In Press; DOI: 10.12659/MSM.943089
14 Mar 2024 : Clinical Research
Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in IndonesiaMed Sci Monit In Press; DOI: 10.12659/MSM.943895
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952