30 March 2007
Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy
Shahnaz Aali, Payam Khazaeli, Fatemeh Ghasemi, Anahita MehdizadehMed Sci Monit 2007; 13(4): CR191-194 :: ID: 481104
Abstract
Background:Magnesium sulfate is used for seizure therapy and prophylaxis in women with eclampsia and pre-eclampsia worldwide. Magnesium may act by opposing calcium-dependent arterial constriction and may also antagonize the increase in intracellular calcium concentration. The objectives were to study the alterations in serum ionized magnesium and calcium and their relationship in patients with severe pre-eclampsia/eclampsia receiving magnesium sulfate therapy.
Material/Methods:Fifty patients in singleton pregnancy with severe pre-eclampsia or eclampsia who were candidates for intravenous magnesium sulfate infusion were studied. Serum ionized magnesium and calcium concentration were determined in blood samples taken before magnesium sulfate infusion, 30 and 240 minutes after the initiation of the infusion, and 4 hours after discontinuation of the therapy. Repeated-measure ANOVA, paired t-test, and Pearson’s correlation coefficient were used to analyze the data.
Results:Mean baseline levels of ionized magnesium and ionized calcium were 1.3±0.5 mEq/l and 3.8±0.5 mg/dl, respectively. The mean concentration of ionized magnesium changed significantly at the stated intervals, while mean ionized calcium values did not. Significant correlation was found between ionized calcium and magnesium four hours after the initiation of magnesium sulfate infusion and after discontinuation of the therapy.
Conclusions:Magnesium ion does not appear to exert its therapeutic effect in pre-eclampsia/eclampsia by substantially modulating serum ionized calcium. However, the effect of exogenous Mg on intracellular calcium cannot be ruled out.
Keywords: Analysis of Variance, Calcium - blood, Eclampsia - drug therapy, Magnesium - blood, Magnesium Sulfate - therapeutic use, Pre-Eclampsia - drug therapy, Pregnancy, Time Factors
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952