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The infl ammatory response: An effi cient way of life

María-Angeles Aller, Jorge-Luis Arias, Fernando Sánchez-Patán, Jaime Arias

Med Sci Monit 2006; 12(10): RA225-234

ID: 459206


The successive pathophysiological mechanisms that develop in the interstitium of tissues when these
undergo acute post-traumatic infl ammation are considered increasingly complex trophic functional
systems for using oxygen. The nervous or immediate functional system presents ischemia-revascularization
and edema, which favor nutrition by diffusion through injured tissue. In this phase of the infl ammatory response, while the progression of the interstitial edema produces progressive distancing of the epithelial cells from the capillaries, it simultaneously enhances lymphatic circulation,
which assumes an unusually important role. During immune system function, tissue nutrition is carried out by leukocytes through symbiosis with bacteria. Improper use of oxygen persists in this immune phase. Activated phagocytes would require anaerobic glycolysis as the main source of ATP for their functions. During this immune phase, lymphatic circulation still plays a major role. The dilatation of lymphatics may be mediated by cytokines, leuokotrienes, and prostaglandins produced at the trauma site by activated resident and infi ltrating cells. Finally, the endocrine functional system facilitates the arrival of oxygen, transported by red blood cells and capillaries. Their trophic potential permits the tissue specialization required for tissue repair to take place. However, if complications occur during the evolution of acute infl ammation, the tissues could go back to using more primitive trophic mechanisms. In summary, the ability of the interstitial tissue to express increasingly complex nutritional systems in relation to oxygen use could refl ect the importance of this space as a battleground for infl ammation and, as a result, for evolution.

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