01 September 2003
Role of respiratory syncytial virus In respiratory tract infections pathogenesis in infants and small children
Grażyna Łuczak, Ewa Kozielska, Joanna Tyl, Anna Borkowska, Anna Galińska, Wojciech Radys, Zbigniew BohdanMed Sci Monit 2003; 9(4): 44-47 :: ID: 428636
Abstract
Background: Respiratory Syncytial Virus (RSV) is a common etiological agent of respiratory infections in neonates and small chil-dren.The aim of the study was to evaluate: frequency and clinical outcome of RSV infections in children, risk factors and coincidence with atopy and humoral immunodeficiency. Material/Methods: Patient ’s history, changes on physical examination, laboratory investigation, chest x-ray, serum IgA, IgG, IgM, IgE levels and specific IgM and IgG antibodies against RSV were analysed in 160 children, aged 2 to 36 months, with respiratory infection.Results: RSV infection was diagnosed on the basis of specific anti-RSV IgM antibodies appearance or increasing anti-RSV IgG level. The group of 61 children with RSV infection included: 13 (21.3%) premature infants, 14 (22.7%) children less than 2 months old and 32 (52.3%) patients over 12 months of age. The main clinical manifestations were: wheezing (obturative) bronchitis (75.4%), pneumonia (44.3%) or both (32.8%). Eight cases of severe bronchiolitis among the youngest infants were noted. Leukocytosis was observed in 77% and increased CRP level in 23% of children. Serum IgA and IgM levels were normal in 82%, IgG in 95.1% and total IgE level in 47.5% of patients. Increased IgE level was observed in 52.5%. Only 26.2% of these children demonstrated clinical features of atopy.Conclusions: RSV infection, usually obturative bronchitis or pneumonia,is commonly observed in young children. Severe bronchi-olitis may occur. Coincidence frequency of RSV infection with total serum IgE elevation and atopy needs further investigation.
Keywords: RSV, Respiratory Tract Infections, Immunoglobulins, children
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952