Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 2000

Levels of serum total cholesterol and LDL-cholesterol in patients with major depression in acute period and remission.

Jolanta Rabe-Jabłońska, Irena Poprawska

Med Sci Monit 2000; 6(3): CR539-547 :: ID: 421312

Abstract

The aim of the study was to determine the level of total cholesterol andLDL-cholesterol in blood samples taken from 102 patients with recurrent major depression (according toDSM-IV). The analysis was performed during the acute period of major depression in 3 subgroups: withand without suicidal ideation (S+, S-), and after suicidal attempts (AS), and during remission of depressivesymptoms. Putative correlations between the level of total cholesterol and severity of depressive symptomsand between total serum cholesterol and LDL-cholesterol and suicidal risk were evaluated. The patientsdid not suffer from any additional disorders, factors such as specific diet or pharmacotherapy, whichcould influence the levels of lipids, were absent. The subgroups were identified using clinical evaluation,medical records and Hamilton Depression Rating Scale--HAMD-S as well as a subscale of MMPI-DMS. Biochemicalanalyses were performed twice in all patients, in the acute period, before pharmacotherapy and aftereffective pharmacotherapy, in remission. The following parameters were evaluated: total serum cholesteroland LDL-cholesterol, T3, T4, TSH, ALT, AST, proteinogram. In all depressed patients with acute depressionsymptoms, low levels of total cholesterol and LDL-cholesterol were shown. The level of total cholesterol160 mg/dl or less and the level of LDL-cholesterol 100 mg/dl or less were observed in persons with suicidalbehavior only (S+ and AS). Low total cholesterol and LDL-cholesterol levels in persons in the acute periodof major depression provided a useful parameter of suicide risk. A significant statistical correlationbetween the low level of total cholesterol and suicidal ideation was also found (r = 0.82, p < 0.05)as well as between the low level of serum total cholesterol and severity of depression, as evaluatedby HAMD-S (r = 0.27, p < 0.05). During the remission of depressive symptoms, total cholesterol leveland LDL-cholesterol increased significantly (p < 0.05) but a significant difference (p < 0.05) betweensubgroups (S-, S+, AS) were still observed. Low total cholesterol and LDL-cholesterol levels in remissionin persons with the diagnosis of recurrent major depression may help to estimate the risk of suicidalbehavior in the next depressive disorder. Possibly, low level of serum total cholesterol is a stablefeature in some persons with recurrent major depression, probably dependent on their predisposition toautoaggression and presence of depressive disorder.

Keywords: Blood Proteins, Cholesterol, Depressive Disorder, Lipoproteins, LDL Cholesterol, MMPI, Psychiatric Status Rating Scales, Recurrence, thyrotropin, thyroxine, Triiodothyronine

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750