Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 2004

Efficacy of a topical suspension of bacterial antigens for the management of recurrent eczema in children

Renzo Mora, Luisa Bellussi, Francesco Maria Passali, Barbara Crippa, Francesco Mora, Maria Paola Cordone, Marco Barbieri

Med Sci Monit 2004; 10(9): PI99-103 :: ID: 11747

Abstract

Background:The aim of this study was to compare the efficacy and safety of a topical suspension of bacterial antigens for the management of recurrent eczema in children.Material/Methods: Eighty pediatric patients, aged between 2 and 6 years, with a history of recurrent external auditory eczema, were enrolled in this study. Congenital immune deficiences, treatment with corticosteroids, immunostimulant or immunosuppressive agents in the past 6 months, and bronchopulmonary disease were considered as exclusion criteria. The patients were randomized to receive topical suspension of bacterial antigens (Lantigen B) (Group A) or placebo (physiological solution) (Group B). The efficacy parameters were evaluated before, at the end of, and one year after the beginning of the therapy. All the children underwent clinical examinations, blood test, skin prick tests (SPT), and clinical evaluation using the clinical score proposed by Rajka and Langeland, considering the intensity, extent, and course of lesions.Results: In Group A, using the statistical Wilcoxon test, we saw an improvement in the clinical items measured. It is important to consider that the patients were allowed to receive concomitant medications to treat acute episodes, which may have partially contributed to the positive results obtained.Conclusions: A topical suspension of bacterial antigens was significantly more effective than placebo in the treatment of recurrent eczema in children.

Keywords: Administration, Topical, Antigens, Bacterial - administration & dosage, Antigens, Bacterial - immunology, Antigens, Bacterial - therapeutic use, Child, Child, Preschool, Eczema - drug therapy, Eczema - immunology, Eczema - pathology, Placebos, Recurrence, Administration, Topical, Antigens, Bacterial - therapeutic use, Child, Child, Preschool, Eczema - pathology, Placebos, Recurrence

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750