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eISSN: 1643-3750

Mechanical Stimulus-Induced Wthdrawal Behavior Increases Subsequent Pre-Stimulus Local Field Potential Power in the Rostral Anterior Cingulate Cortex in Unanesthetized Rats

Zui Shen, Jing Sun, Boyi Liu, Yongliang Jiang, Yuanyuan Wu, Jialing Wang, Xiaomei Shao, Jianqiao Fang

(Department of Neurobiology and Acupuncture Research, The 3rd Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China (mainland))

Med Sci Monit 2017; 23:1099-1105

DOI: 10.12659/MSM.903292

Published: 2017-03-02

BACKGROUND: The rostral anterior cingulate cortex (rACC) is important in pain expectation. Previous studies demonstrated that mechanical stimulus-induced withdrawal behaviors are spinally-mediated nocifensive reflexes in rats, but it is not known whether pain expectation is influenced by withdrawal behaviors.
MATERIAL AND METHODS: We reanalyzed previous mechanosensitivity measurements of 244 rats measured 5 times in succession. To study neural oscillation in the rACC, 1 recording microwire array was surgically implanted. Then, we simultaneously recorded the local field potential (LFP) of the rACC over the course of multiple withdrawal behaviors in unanesthetized rats.
RESULTS: From our previous withdrawal behavioral data in 244 rats, we observed that the distributions of paw withdrawal thresholds (PWTs) were denser and more concentrated after the first withdrawal behavior. Compared to the first mechanical stimulus, increased neuronal synchrony and a stronger delta band component existed in each pre-stimulus LFP in the rACC during subsequent stimuli.
CONCLUSIONS: Pain expectation could be involved in withdrawal behaviors, which is related to increased total power and delta band power of the subsequent pre-stimulus LFPs in the rACC.

Keywords: Cognitive Science, Cone-Beam Computed Tomography, Gyrus Cinguli, Microelectrodes, Pain