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Diagnostic Values of Serum Levels of Homocysteine and Uric Acid for Predicting Vascular Mild Cognitive Impairment in Patients with Cerebral Small Vessel Disease

Ting Wang, Zhong-Wu Sun, Liang-Qing Shao, Xiao-Bin Xu, Yang Liu, Mao Qin, Xiang Weng, Yong-Xiang Zhang

(Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland))

Med Sci Monit 2017; 23:2217-2225

DOI: 10.12659/MSM.901652

Published: 2017-05-10

BACKGROUND: This study aimed to investigate the diagnostic values of serum levels of Hcy and UA for predicting vascular mild cognitive impairment (VMCI) in patients with cerebral small vessel disease (SVD).
MATERIAL AND METHODS: We selected 172 cerebral SVD patients and divided them into a VMCI group and a non-VMCI group. Eighty-six healthy individuals without nervous system diseases were selected as the control group. Enzymatic cycling method was performed to detect serum Hcy and UA levels. Serum levels of folic acid (FOA) and vitamin B12 (VitB12) were detected by chemiluminescence immunoassay. Montreal cognitive assessment (MoCA) was applied to evaluate the cognitive function. The ROC curve was used to evaluate the diagnostic values of serum Hcy and UA levels for predicting VMCI. Logistic regression analysis was used to determine the possible risk factors.
RESULTS: Compared with the non-VMCI and control groups, serum FOA and VitB12 levels were lower and serum Hcy and UA levels were higher in the VMCI group. AUC values of serum Hcy and UA levels were 0.703 and 0.829, respectively. Serum Hcy and UA levels were negatively correlated with serum FOA and VitB12 levels, total MoCA score, and subscores on visuospatial ability and executive function, on language ability and on delayed recall, and they were positively correlated with serum cholesterol (CH) level. Serum Hcy and UA levels were indicated as risk factors for VMCI in cerebral SVD patients.
CONCLUSIONS: These results suggest that serum Hcy and UA levels may serve as predictive factors for VMCI in cerebral SVD patients.

Keywords: Aminohippuric Acids, Blood Vessels, homocysteine