26 March 2017 : Clinical Research
Serum Endocan as a Predictive Marker for Decreased Urine Volume in Peritoneal Dialysis Patients
Satoru Oka12ABCDEF, Yoko Obata123ABCDEF*, Shuntaro Sato4CD, Kenta Torigoe12B, Miki Sawa12B, Shinichi Abe1B, Kumiko Muta1B, Yuki Ota12B, Mineaki Kitamura15B, Satoko Kawasaki1B, Misaki Hirose1B, Tadashi Uramatsu1B, Hiroshi Mukae2G, Tomoya Nishino12ADEGDOI: 10.12659/MSM.900693
Med Sci Monit 2017; 23:1464-1470
Abstract
BACKGROUND: Endocan is expressed in vascular endothelial cells, and its expression is enhanced following endothelial injury via inflammatory cytokines. Subsequently, endocan is secreted into the circulation. Thus, serum endocan levels are considered a marker of endothelial injury. However, to the best of our knowledge, no data on the serum endocan levels in peritoneal dialysis (PD) patients are available.
MATERIAL AND METHODS: This study included 21 PD patients who underwent peritoneal equilibration test (PET) more than once between 2011 and 2015. Serum samples were collected from each patient, and the 24-h urine volume was measured at the time of PET. Serum endocan levels were measured using enzyme-linked immunosorbent assay (ELISA) at the time of the first PET, and their relationship with clinical data or the extent of urine volume decline (mL/year) was analyzed retrospectively.
RESULTS: Serum endocan levels were positively correlated with proteinuria level, serum creatinine level, serum tumor necrosis factor (TNF)-α level, β2-microglobulin level, and PD drainage volume, but not with urine volume at baseline. The extent of decline in urine volume was significantly associated with serum endocan level, proteinuria level, serum creatinine level, and serum TNF-α level at baseline in a simple linear regression analysis. Moreover, multiple linear regression analysis showed that the serum endocan level and proteinuria level at baseline were independent predictors for the extent of decline in urine volume.
CONCLUSIONS: The results of this study indicate that serum endocan level and proteinuria level may be useful predictive markers for decreased urine volume in PD patients.
Keywords: Endocan, Peritoneal Dialysis, endothelial injury, Residual Renal Function, Urine volume
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