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Effect of Ramadan fasting on serum concentration of apelin-13 and new obesity indices in healthy adult men

Ahmet Celik, Edibe Saricicek, Vahap Saricicek, Gokhan Ozdemir, Elif Sahin, Selim Bozkurt, Mehmet Okumus, Mustafa Haki Sucakli, Gurkan Cikim, Yasemin Coskun, Mustafa Saygin Deniz, Ekrem Dogan, Metin Kilinc

(Department of Medical Biochemistry, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey)

Med Sci Monit 2014; 20:337-342

DOI: 10.12659/MSM.890139

Published: 2014-02-28

Background: The aim of this study was to determine how Ramadan fasting (RF) affected the recently described new obesity indices [visceral adiposity index (VAI), waist circumference to height ratio (WHtR), body adiposity index (BAI)], and serum concentration of apelin-13 (RF) in healthy adult men.
Material and Methods: For this purpose, 42 healthy adult men were selected. Anthropometric parameters were measured and a sample of venous blood was obtained for biochemical assays on the first and last days of Ramadan.
When all subjects were evaluated, all anthropometric parameters changed except VAI. Serum apelin-13, triglyceride (TG), HDL-cholesterol (HDL-C), and insulin levels did not change. When patients were divided into 3 groups according to body mass index (BMI), BAI decreased in normal-weight subjects and WHtR decreased in other groups, but VAI and apelin-13 did not change in any groups.
Results: We demonstrate for the first time that while some anthropometric parameters changed, VAI and serum apelin-13 levels did not change with RF. BMI, waist circumference (WC), TG, and HDL-C were evaluated together in calculation of VAI. TG, VAI, and HDL-C remained unchanged by RF. Even if body weight (BW) and BMI decreased, apelin-13 was not affected by RF. The data on serum apelin-13 may have been influenced by the small-percentage decrease in BW, as well as insignificant improvements in metabolic parameters such as lipid profiles, glucose, and insulin.
Conclusions: We found that Ramadan fasting in healthy adult men was associated with significant decreases in BW, BMI, WHtR, and BAI, but we found no significant changes in VAI and serum apelin-13 concentrations.

Keywords: Intra-Abdominal Fat, Adiposity - physiology, Fasting, Adult, Body Mass Index, Cholesterol, HDL - blood, Fasting - blood, Humans, Intercellular Signaling Peptides and Proteins - blood, Intra-Abdominal Fat - metabolism, Islam, Male, Turkey, Waist-Height Ratio