eISSN: 1643-3750


Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders

Radek Ptacek, Hana Kuzelova, George B. Stefano

Med Sci Monit 2011; 17(9): RA215-220

DOI: 10.12659/MSM.881925

Published: 2011-08-22

Dopamine receptors control neural signals that modulates behavior. Dopamine plays an important role in normal attention; that is the reason for studying the genes of the dopaminergic system, mainly in connection with disorders of attention. DRD4 influences the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders. Associations were found with ADHD (attention deficit hyperactivity disorder), substance dependences, several specific personality traits, and reaction to stress. These findings have implications for pharmacogenetics. This article reviews the principle published associations of DRD4 variants with psychiatric disorders.

Keywords: Receptors, Dopamine D4 - genetics, Personality - genetics, Mental Disorders - genetics, Humans, Genetic Predisposition to Disease, Attention Deficit Disorder with Hyperactivity - genetics, Stress, Psychological - genetics