30 September 2009
Prognostic value of clinical, laboratory, and morphological factors in patients with primary focal segmental glomerulosclerosis - distribution of pathological variants in the Croatian population
Jadranka Vlasić-MatasABCDEF, Merica Glavina DurdovBDEF, Vesna CapkunC, Kresimir GalesićABDFMed Sci Monit 2009; 15(10): PH121-128 :: ID: 878197
Abstract
Background
Scant data are available on the prognosis and distribution of subtypes of focal segmental glomerulosclerosis (FSGS) using the new Columbia classification in European populations. We assessed the predictive value of the clinical, laboratory, and morphological data obtained at the time of diagnosis, established on the basis of kidney biopsy, for the prognosis of primary FSGS.
Material and Method
Sixty adults with FSGS were included in the study. Patients' clinical status, routine laboratory data, and histopathological findings were correlated with patients' remission status after a 5-year follow-up and patients' injury score (IS).
Results
Thirty-eight patients had remission of the disease and 22 patients did not. A value of IS>0.84 was more often found in patients who did not reach remission, whereas IS <0.34 was more frequent in patients who did reach remission (P=0.002). Serum creatinine and creatinine clearance correlated with IS (P<0.001), but proteinuria showed no correlation. FSGS subtypes were distributed as follows: tip variant in 3 (5%) patients, cellular variant in 4 (7%), not otherwise specified variant in 15 (25%), and perihilar variant in 38 (63%) patients. Collapsing variant of FSGS was not found in any of the patients included in the study.
Conclusions
Injury score is the most reliable prognostic predictor in patients with primary FSGS. Patients with perihilar variant were most frequent, whereas collapsing variant was not found at all in the Croatian population.
Keywords: Inflammation - complications, Immunosuppression, Immunosuppressive Agents - therapeutic use, Hypertension - complications, Glomerulosclerosis, Focal Segmental - pathology, European Continental Ancestry Group, Croatia, Clinical Laboratory Techniques, Adolescent, Remission Induction, young adult
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952