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eISSN: 1643-3750

Nephrotic-range proteinuria with small glomerular fibrillary deposits in a patient on diphenylhydantoin treatment

Ahmet Alper Kiykim, Gultekin Genctoy, Mehmet Horoz, Sibel Sari, Ebru Gok, Banu Coskun, Nejat Yilmaz, Iclal Gurses

Med Sci Monit 2009; 15(8): CS132-134

ID: 878126

Published: 2009-08-01

Background: Although the exact role of the diphenylhydantoin treatment on the immune system is still unclear, prolonged administration of diphenylhydantoin has been suggested to be associated with immune-based disorders and syndromes.
Material and Method: A case of fibrillary glomerulonephritis associated with DPH treatment is reported. This is the first reported case of fibrillary glomerulonephritis associated with this commonly used common anticonvulsive drug.
Conclusions: A more routine surveillance for proteinuria in patients receiving DPH is recommended.

Keywords: Phenytoin - adverse effects, Middle Aged, Periodic Acid-Schiff Reaction, Kidney Glomerulus - ultrastructure, Male, Humans, Glomerulonephritis - pathology, Proteinuria - pathology