30 March 2009
Plasma levels of von Willebrand factor in subjects with isolated impaired fasting glucose
Erkan CobanABCDEF, Feyzi BostanABDEFMed Sci Monit 2009; 15(4): CR194-197 :: ID: 869621
Abstract
Background
It has been shown that an increased von Willebrand factor level reflects endothelial dysfunction and may also have prognostic value in patients with atherosclerotic disease. Impaired fasting glucose is likely a frequent glycemic disorder in the general population and is considered a prediabetic state. Impaired fasting glucose is associated with cardiovascular disease, but it is unclear whether it is an independent risk factor because it commonly coexists with other cardiovascular risk factors present in metabolic syndrome. The present study was designed to evaluate the von Willebrand factor level in subjects with isolated impaired fasting glucose compared to healthy normoglycemic subjects.
Material and Method
We selected 48 subjects with isolated impaired fasting glucose and 48 normoglycemic control subjects matched for age, sex, and body mass index. We measured the von Willebrand factor level in all subjects.
Results
The von Willebrand factor level was significantly higher in the isolated impaired fasting glucose group than in the control group (111.08%+/-52.78% vs 74.08%+/-48.47%) (P=0.001). The von Willebrand factor level was also positively correlated with fasting plasma glucose in the isolated impaired fasting glucose group (P=0.004).
Conclusions
Our results show that subjects with isolated impaired fasting glucose have higher von Willebrand factor levels, which suggests endothelial dysfunction.
Keywords: von Willebrand Factor - metabolism, Fasting, Case-Control Studies, Blood Glucose - metabolism
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952