30 March 2009
Effect of orally administered propylthiouracil in pregnant and lactating rats on isolated aorta contractility of their adult male offspring
Mohammad KhaksariADEG, Morteza ShafieeABCDEF, Asghar GhasemiBCDE, Saleh Zahedi AslABCDEFGMed Sci Monit 2009; 15(4): BR123-127 :: ID: 869611
Abstract
Background
The effect of propylthiouracil (PTU) administration to pregnant and lactating rats on isolated aorta contractility of their adult offspring was investigated.
Material and Method
Three groups of female rats were selected; in the fetal group (FG), PTU was added to their drinking water during gestation; in the neonatal group (NG), PTU was added to the mothers' drinking water for 25 days after delivery; untreated rats were controls (CG). Thyroid hormone concentrations were measured in the sera of the mothers and their adult offspring. Aortic contractility of the offspring was measured with an isometric transducer in the presence of different concentrations of potassium chloride (KCl) and phenylephrine.
Results
The mothers were hypothyroid at the time of PTU cessation. Thyroid hormone levels in offspring were not significantly different from those of controls except for TSH, which was significantly (p<0.05) higher in the FG offspring. Recorded tension in FG offspring with 5, 10, 20, 40, and 60 mmol/l KCl were 0.21+/-0.02, 0.75+/-0.07, 1.07+/-0.07, 1.38+/-0.08, and 1.5+/-0.09 g/mm2, respectively, significantly (p<0.05) lower than the control values (0.43+/-0.05, 1.19+/-0.17, 1.76+/-0.23, 2.06+/-0.22, 2.5+/-0.09). Aortic contractility with 10-8, 10-7, and 10-6 mmol/l of phenylephrine in the FG offspring were 0.6+/-0.13, 1.4+/-0.15, and 1.8+/-0.15 g/mm2, significantly lower than control values (1.24+/-0.19, 2.3+/-0.25, 2.6+/-0.28). Contractility of the NG aorta did not differ significantly from controls.
Conclusions
Hypothyroidism during the fetal period has significant effects on the differentiation and development of the vascular bed (aorta), the long-term effects of which can still be observed during adulthood.
Keywords: Rats, Wistar, Propylthiouracil - pharmacology, Pregnancy, Potassium Chloride - pharmacology, Phenylephrine - pharmacology, Maternal Exposure, Muscle Contraction - drug effects, Lactation, Aorta - physiology, Administration, Oral, Thyroid Hormones - blood
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952