Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

Effect of septic shock on lipolytic activity in rats' blood and adipose tissue

Leonard Kraśnik, Janusz Paluszak

Med Sci Monit 1999; 5(5): BR845-849 :: ID: 503270

Abstract

The metabolic study of septic shock indicates an intensification of anaerobic glycolysis, gluconeogenesis, proteolysis and limitation of lipid utilisation as a source of energy. The object of this study is the influence of a septic shock on lipolytic activity in the rats` blood and adipose tissue. The septic shock was developed by intraperitoneal injection of bacterial suspension (107 E. coli). The blood was taken in the hyperdynamic (I phase) and hypodynamic (II phase) period of a septic shock and the levels of glucose, insulin, free fatty acids (FFA), triglycerides (TG), total cholesterol (TC) and its fractions (HDL, LDL), lipolytic activity of serum (LAS) and lipid mobilising activity (LMA) were determined. Results: the glucose concentration in blood was increased in phase I of the septic shock to 8.70±1.30 mmol/l, in phase II it was decreased to 2.93±0.42 mmol/l. The insulin level of blood serum was increased to 16.15±3.60 µU/ml in phase I of the septic shock, in phase II, the insulin level was decreased to the level which was observed in the control group (8.15±1.71 µU/ml). The concentration of serum TC progressively decreased during the septic shock, as well as the HDL-cholesterol concentration. The concentration of the LDL-cholesterol fraction was increased to 0.26±0.01 mmol/l in phase I, and in phase II it decreased to 0.14±0.03 mmol/l. We demonstrated the increase of serum TG to 1.93±0.65 mmol/l with its reduction of FFA to 0.37±0.06 mmol/l in phase I of the septic shock. In phase II, the TG concentration decreased to 1.34±0.12 mmol/l, but it was still higher than in the control group (0.92±0.10 mmol/l) and the FFA concentration was increased to 1.22±0.26 mmol/l. In phase I of the septic shock, the LAS was increased to 1.88±0.52 µm/ml/h, in phase II it was decreased to 0.02±0.01 µm/ml/h. The LMA progressively increased during the septic shock and in phase II it reached 0.21±0.07 µm/ml/h.

Keywords: Lipid Metabolism, lipolytic activity, septic shock

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750