Effect of septic shock on lipolytic activity in rats' blood and adipose tissue
Leonard Kraśnik, Janusz PaluszakMed Sci Monit 1999; 5(5): BR845-849 :: ID: 503270
Abstract
The metabolic study of septic shock indicates an intensification of anaerobic glycolysis, gluconeogenesis, proteolysis and limitation of lipid utilisation as a source of energy. The object of this study is the influence of a septic shock on lipolytic activity in the rats` blood and adipose tissue. The septic shock was developed by intraperitoneal injection of bacterial suspension (107 E. coli). The blood was taken in the hyperdynamic (I phase) and hypodynamic (II phase) period of a septic shock and the levels of glucose, insulin, free fatty acids (FFA), triglycerides (TG), total cholesterol (TC) and its fractions (HDL, LDL), lipolytic activity of serum (LAS) and lipid mobilising activity (LMA) were determined. Results: the glucose concentration in blood was increased in phase I of the septic shock to 8.70±1.30 mmol/l, in phase II it was decreased to 2.93±0.42 mmol/l. The insulin level of blood serum was increased to 16.15±3.60 µU/ml in phase I of the septic shock, in phase II, the insulin level was decreased to the level which was observed in the control group (8.15±1.71 µU/ml). The concentration of serum TC progressively decreased during the septic shock, as well as the HDL-cholesterol concentration. The concentration of the LDL-cholesterol fraction was increased to 0.26±0.01 mmol/l in phase I, and in phase II it decreased to 0.14±0.03 mmol/l. We demonstrated the increase of serum TG to 1.93±0.65 mmol/l with its reduction of FFA to 0.37±0.06 mmol/l in phase I of the septic shock. In phase II, the TG concentration decreased to 1.34±0.12 mmol/l, but it was still higher than in the control group (0.92±0.10 mmol/l) and the FFA concentration was increased to 1.22±0.26 mmol/l. In phase I of the septic shock, the LAS was increased to 1.88±0.52 µm/ml/h, in phase II it was decreased to 0.02±0.01 µm/ml/h. The LMA progressively increased during the septic shock and in phase II it reached 0.21±0.07 µm/ml/h.
Keywords: Lipid Metabolism, lipolytic activity, septic shock
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952