Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 October 2007

The effect of gastric overfilling on the pharyngo-esophageal and lower esophageal sphincter: A possible factor in restricting food intake

Ahmed Shafik, Ali A Shafik, Olfat El Sibai, Ismail A Shafik

Med Sci Monit 2007; 13(10): BR220-224 :: ID: 502338

Abstract

& α Background: How afferent activity in the gut achieves the required ingestion control has not been established. The authors hypothesized that gastric overdistension effects an increase in pharyngo-esophageal and lower esophageal sphincter activity aimed at inhibiting ingestion.
Material/Methods: The study comprised 16 mongrel dogs. Under anesthesia, one balloon-tipped catheter was placed in the stomach, another within the lower esophageal sphincter (LES), and a third within the pharyngo-esophageal sphincter (PES). The gastric balloon was filled with H[sub]2[/sub]O in increments of 10 ml and LES and PES pressures were recorded. The test was repeated after individual gastric, LES, and PES anesthetization.
Results: Gastric balloon filling with more than 20 ml of H[sub]2[/sub]O showed progressively increasing LES pressure up to 110–120 ml of gastric filling, beyond which the pressure exhibited no further increase upon incrementally increased gastric filling volume. PES pressure increased only with a gastric filling volume exceeding 100–110 ml and continued to increase with increasing gastric filling. Gastric filling as above while the stomach, LES, and PES were separately anesthetized produced no LES or PES pressure response.
Conclusions: LES and PES appear to contract on gastric filling; PES responds only to excess gastric filling. It seems that LES and PES response to gastric filling is mediated through a reflex which the authors call the "gastro-esophagopharyngeal reflex" (GEPR). Changes in the evoked response would indicate a defect in the reflex pathway. GEPR might thus serve as an investigative tool in the diagnosis of gastroesophageal disorders, although further studies are required. 

Keywords: Dogs, Catheterization, Esophageal Sphincter, Lower - physiopathology, Feeding Behavior - physiology, Pharynx - physiology, Pressure, Stomach - physiology, Water

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750