01 September 1998
Detection of specific IgM-CLASS antitreponemal antibodies in blood serum of patients with syphilis with the use of CAPTIA Syphilis-M reaction and comparing it with VDRL, FTA-ABS and TPHA reactions
Mieczysław Gibowski, Ryszard Żaba, Tatiana MachońkoMed Sci Monit 1998; 4(5): PI882-888 :: ID: 502060
Abstract
The aim of the study was to observe specific IgM-class antitreponemal antibodies in blood serum of patients with syphilis, with the use of immunoenzyme reaction CAPTIA Syphilis-M and to compare it with other routine syphilis serological reactions (VDRL, FTA-ABS and TPHA). The authors investigated the serum of the total of 200 patients with syphilis (123 men and 77 women), including 110 patients with early syphilis (not treated so far) and 90 patients with late syphilis (14 not treated subjects and 76 treated subjects). The patients were divided into subgroups depending on syphilis type. Examinations were performed with immunoenzyme reaction CAPTIA Syphilis-M and its results were compared with those obtained with the use of VDRL, FTA-ABS and TPHA reactions. Positive CAPTIA Syphilis-M results were observed in 90% of patients with early syphilis, and in only 11% of patients with late syphilis. As far as primary syphilis is concerned, this reaction was positive in 100% of subjects, while VDRL - in 56%, and TPHA and FTA-ABS - in 67% of cases. A slightly earlier negativity of CAPTIA Syphilis-M reaction when compared with VDRL was observed after therapy with penicillin. The authors presume that CAPTIA Syphilis-M is particularly useful in the diagnostics of early syphilis (especially primary syphilis) and that it is a more sensitive index of treatment efficiency than VDRL reaction.
Keywords: syphilis, serological reactions, CAPTIA Syphilis-M reaction
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952