Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1997

Gamma-sigma+ T cells and humoral response to hsp 65 and hsp 70 in subacute sclerosing panencephalitis

Urszula Fiszer, Grażyna Korczak-Kowalska, Wanda Sobczyk, Wanda Sobczyk

Med Sci Monit 1997; 3(5): CR677-681 :: ID: 501590

Abstract

Several hypothesis have been put forward to explain the pathogenesis of subacute sclerosing panencephalitis (SSPE). However, the mechanisms leading to the lack of elemination of the virus still remain unclear. Due to the protection function of gd+ T cells in infections, the present investigation examined the percent of gd+ T cells out of all T cells and their characteristics in peripheral blood by flow cytometry. Heat shock proteins (hsps) play an important role in the response of neurons to different factors, therefore the existence of IgG and IgM antibodies against hsps in sera was examined by the ELISA in 14 patients with SSPE. These investigations were also carried out on a control group patients with other neurological diseases (OND). In SSPE patients the average percentage of gd+ T lymphocytes in the peripheral blood was higher (6.9±5.4%) in comparison with OND (1.9±1.9%). The percentage of subtype Vd1/gd+ T cells amounted to 18.5±17.0% in the SSPE patients and to 33.5±27.1% in OND. Active gd+ T cells (CD25+gd+T) were found in 2 of 12 patients with SSPE and in 5 of 14 patients with OND. No differences were found between mean ELISA ratios for IgG and IgM antibodies in the sera of SSPE and OND patients tested for antibodies against hsp 65 and hsp 70. The above data comes from patients with advanced disease treated with immunomodulatory drugs; they confirm a disturbances of cell response in patients with SSPE.

Keywords: gamma-sigma+ T cells, heat shock proteins, SSPE

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750