Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1997

Effects of interaction between cadmium and selenium on hepatic metabolism in mice. Part I: The study on DNA, RNA and protein synthesis activities in mouse hepatocytes

Mariusz Skowerski, Janusz Konecki, Kazimierz Czechowicz, Maria Głowacka

Med Sci Monit 1997; 3(5): BR642-647 :: ID: 501529

Abstract

Industrial wastes include heavy metals such as cadmium (Cd). Studies on Cd revealed that it is almost exlusively toxic in its effects on metabolism. Selenium (Se) a presequisite for proper functioning of the organism. Several data indicate that Se may be a potential suppressor of noxious Cd effects.We investigated the effects of dietary Cd intoxication on the incorparation of precursors of DNA, RNA and protein synthesis in mouse hepatocytes and compared them with the results of Cd-Se interaction.The results demonstrate that compared to controls 3H-thymidine uptake in the hepatocyte was decreased by 17% in the Cd-diet mice and increased by 13% and 2% in the Sediet and the Cd-Se-diet mice respectively. The 3H-uridine uptake was enhanced by 84% in the Cd-diet group (pM0.05) and by 78% (p<0.05) in the Cd-Se-diet group, but it was decreased by 10% in the Se-group. The 3H-alanine uptake by proteins was increased by 82% (p<0.05) in the Cd-group and was the highest in the Se-group (126%) (p<0.05). In the Cd-Se-diet group the uptake was decreased by 24%. We concluded that in mouse hepatocytes Cd intoxication distorted the incorporation of precursors of nucleic acids and protein synthesis. However, Cd-Se intoxication showed that selenium suppressed the toxic effects of cadmium.

Keywords: Cadmium, Selenium, Liver, Nucleic Acids, Proteins

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750