01 July 1997
Reduction of apoptosis of in vitro cultured peripheral blood lymphocytes of HIV positive individuals by thymocartin
Bela Szende, Attila Horvath, Karoly Nagy, Jozsef Bocsi, Ilona Kovalszky, Eva BarabasMed Sci Monit 1997; 3(4): BR456-459 :: ID: 501321
Abstract
Background: Apoptotic (natural or programmed) cell death of lymphocytes contributes to an immune decline of HIV-infected persons. Active fragments of thymopoietin may reduce apoptosis and slow down this progress of immune decline.
Material/Methods: In vitro studies were performed in order to investigate the apoptosis-reducing effect of a new active thymopoietin fragment, Thymocartin (Arg-Lys-Asp-Val). Separated peripheral blood lymphocytes of 10 asymptomatic HIV-positive and 7 HIV-negative persons were cultured. Unstimulated, IL-2-stimulated and IL-2-stimulated plus 0.1 and 0.001 µg/ml Thymocartin-treated cells were investigated for apoptosis by morphological (HE, Apop-Tag), flow cytometric and agarose DNA fragmentation methods.
Results: Unstimulated lymphocytes of HIV-positive persons showed higher apoptotic activity than those of HIV-negative persons. IL-2-stimulation increased the apoptotic rate in 7 HIV-positive and 1 HIV-negative individuals. Thymocartin reduced the apoptotic activity in 8 HIV-positive and 1 HIV-negative case.
Conclusions: Thymocartin reduces the apoptotic activity in lymphocytes of HIV-positive patients in vitro. This compound may have the same effect in vivo and may prolong the asymptomatic period of HIV-infected patients.
Keywords: HIV-infection, thymocartin
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952