01 July 1996
Idiopathic focal segmental glomerulosclerosis in adults: a quantitative study
Marian Danielewicz, Małgorzata Wągrowska-DanielewiczMed Sci Monit 1996; 2(4): CR447-452 :: ID: 499932
Abstract
Fifteen renal biopsy specimens obtained from adult patients with idiopathic focal segmental glomerulosclerosis (FSGS) for whom both light and electron microscopy as well as immunofluorescence microscopy and full clinical data were available were examined quantitatively. Six biopsy and nine autopsy specimens of the normal kidneys were used as a control. Morphometric investigations were performed by means of a computer image analysis system to determine the significance of glomerular enlargement and mesangial alterations in adult FSGS as well as to study whether serum creatinine and interstitial fibrosis could correlate with the changes in quantitatively analyzed glomeruli. The morphometric comparisons of the glomeruli and renal interstitial tissue in patients with FSGS and controls revealed that the mean values of total glomerular area, total glomerular cells per total glomerular area, total glomerular cells per unit of glomerular area, mesangium (% of total glomerular area) and relative interstitial volume were in FSGS increased, most of them significantly. There were significant positive correlations between interstitial volume and serum creatinine (r&eguals;0.64, P < 0.01), between interstitial volume and glomerular mesangium (r=0.75, P < 0.002) and between total glomerular area and serum creatinine (r=0.54, P < 0.05). Correlation between interstitial volume and total glomerular cells per unit of glomerular area was weak and not significant (r=0.49, P - NS). Our morphometric data confirm that glomerular hypertrophy and the extent of interstitial fibrosis may be a valuable predictor of unfavorable evolution of FSGS. Although our findings suggest the role of glomerular mesangium in the mechanisms of interstitial fibrosis, this possible association needs further investigations.
Keywords: Glomerulosclerosis, morphometry
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
15 Mar 2024 : Clinical Research
Impact of One-Lung Ventilation on Oxygenation and Ventilation Time in Thoracoscopic Heart Surgery: A Compar...Med Sci Monit In Press; DOI: 10.12659/MSM.943089
14 Mar 2024 : Clinical Research
Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in IndonesiaMed Sci Monit In Press; DOI: 10.12659/MSM.943895
15 Mar 2024 : Clinical Research
Evaluation of an Optimized Workflow for the Radiofrequency Catheter Ablation of Paroxysmal Atrial FibrillationMed Sci Monit In Press; DOI: 10.12659/MSM.943526
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952