01 July 1996
Effect of ethanol and phenytoin applied jointly in pregnant rats on behaviour of their offspring
Ryszard Szkilnik, Wiesława Felińska, Maria Głowacka, Ryszard BrusMed Sci Monit 1996; 2(4): BR408-414 :: ID: 499905
Abstract
Ethanol and phenytoin ingested in pregnancy may result in long-term adverse effects in offspring termed as "fetal alcohol syndrome" or "fetal hydantoin syndrome" respectively. Particularly vulnerable is the developing central nervous system (CNS). The aim of the present study was to assess the effect of ethanol (oral 10% solution taken freely) and phenytoin (2 and 10 mg/kg s.c.), administered separately and in combination in pregnant rats, on the CNS in their offspring as evaluated with different behavioural methods. The tests have shown an impaired CNS function in 6-week and 3-month old male offspring of mothers given ethanol and phenytoin during pregnancy as compared to that in control animals. Ethanol and phenytoin administered in combination during pregnancy decrease adverse effects observed in animals receiving the compounds separately in the prenatal period. This might be explained by mutual induction of metabolising enzymes due to which smaller amounts of the substances pass across the placenta into the foetus.
Keywords: phenytoin, Ethanol, offspring, behaviour effect
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952